Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Transforming growth factor-beta (TGF-β) plays multiple homeostatic roles in the regulation of
inflammation, proliferation, differentiation and would healing of various tissues. Many studies …

Absorption, distribution, metabolism, and excretion (ADME) are the key biologic processes
for determination of a drug's pharmacokinetic parameters, which have direct impacts on …

Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …

Bladder cancer (BC) is a common and serious type of cancer that ranks among the top ten
most prevalent malignancies worldwide. Due to the high occurrence rate of BC, the …

Lipid-based nanoparticles (LBNPs) are biocompatible and biodegradable vesicles that are
considered to be one of the most efficient drug delivery platforms. Due to the prominent …

Liposomes are nano-sized lipid-based vesicles widely studied for their drug delivery
capabilities. Compared to standard carries they exhibit better properties such as improved …

Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD)
characterized by intestinal inflammation. Increased intestinal levels of the proinflammatory …

Lipid nanoparticles (LNPs) are gaining traction in the field of nucleic acid delivery following
the success of two mRNA vaccines against COVID-19. As one of the constituent lipids on …

Many conditions can benefit from RNA-based therapies, namely, those targeting internal
ribosome entry sites (IRESs) and their regulatory proteins, the IRES trans-acting factors …