Flavonoids are present in fruits, vegetables and beverages derived from plants (tea, red
wine), and in many dietary supplements or herbal remedies including Ginkgo Biloba, Soy …

Numerous studies indicate that moderate red wine consumption is associated with a
protective effect against all-cause mortality. Since oxidative stress constitutes a unifying …

Within the last years, a rapidly growing number of polyphenolic compounds with
neuroprotective effects have been described. Many efforts have been made to explore the …

This article provides an overview of current research on flavonoids as presented during a
workshop entitled,“Flavonoids and Heart Health,” held by the ILSI North America Project …

Drug interactions in oncology are of particular importance owing to the narrow therapeutic
index and the inherent toxicity of anticancer agents. Interactions with other medications can …

This article gives an overview of the potential hazards of polyphenol consumption, as
reported during the round-table discussion at the 1st International Conference on …

P‐glycoprotein (Pgp) is a 170 kDa phosphorylated glycoprotein encoded by human MDR1
gene. It is responsible for the systemic disposition of numerous structurally and …

Despite a lower content of many drug metabolising enzymes in the intestinal epithelium
compared to the liver (eg intestinal CYP3A abundance in the intestine is 1% that of the liver) …

Targeted concurrent inhibition of intestinal drug efflux transporter P-glycoprotein (P-gp) and
drug metabolizing enzyme cytochrome P450 3A4 (CYP3A4) is a promising approach to …

Introduction: Since their initial discovery in 1989, grapefruit juice (GFJ)–drug interactions
have received extensive interest from the scientific, medical, regulatory and lay communities …