Covering: up to early 2011 Streptomycetes and other actinobacteria are renowned as a rich
source of natural products of clinical, agricultural and biotechnological value. They are being …

While the biological functions of most of the secondary metabolites made by streptomycetes
are not known, it is inconceivable that they do not play an adaptive ecological role. The …

Bacterial genes associated with a single trait are often grouped in a contiguous unit of the
genome known as a gene cluster. It is difficult to genetically manipulate many gene clusters …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Natural products and their derivatives play an important role in modern healthcare as
frontline treatments for many diseases and as inspiration for chemically synthesized …

Production of secondary metabolites is a process influenced by several physico-chemical
factors including nutrient supply, oxygenation, temperature and pH. These factors have been …

Although microorganisms are extremely good in presenting us with an amazing array of
valuable products, they usually produce them only in amounts that they need for their own …

Antibiotic resistance poses a tremendous threat to human health. To overcome this problem,
it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and …

An Escherichia coli–actinomycete shuttle vector, pCJW93, was constructed which places
cloned genes under the control of the thiostrepton-inducible tip promoter from Streptomyces …

Metabolic engineering efforts toward rewiring metabolism of cells to produce new
compounds often require the utilization of non-native enzymatic machinery that is capable of …