[HTML][HTML] Natural killer cells and T cells in hepatocellular carcinoma and viral hepatitis: current status and perspectives for future immunotherapeutic approaches
SG Kalathil, Y Thanavala - Cells, 2021 - mdpi.com
Natural killer (NK) cells account for 25–50% of the total number of hepatic lymphocytes,
which implicates that NK cells play an important role in liver immunity. The frequencies of …
which implicates that NK cells play an important role in liver immunity. The frequencies of …
[HTML][HTML] The role of NLRP3 inflammasome in hepatocellular carcinoma
H Zhao, Y Zhang, Y Zhang, C Chen, H Liu… - Frontiers in …, 2023 - frontiersin.org
Inflammasomes play an important role in innate immunity. As a signal platform, they deal
with the excessive pathogenic products and cellular products related to stress and injury. So …
with the excessive pathogenic products and cellular products related to stress and injury. So …
[HTML][HTML] TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer
K Slattery, E Woods, V Zaiatz-Bittencourt… - … for ImmunoTherapy of …, 2021 - ncbi.nlm.nih.gov
Background Natural killer (NK) cells provide important immune protection from cancer and
are a key requirement for particular immunotherapies. There is accumulating evidence that …
are a key requirement for particular immunotherapies. There is accumulating evidence that …
[HTML][HTML] A bispecific antibody targeting GPC3 and CD47 induced enhanced antitumor efficacy against dual antigen-expressing HCC
K Du, Y Li, J Liu, W Chen, Z Wei, Y Luo, H Liu, Y Qi… - Molecular Therapy, 2021 - cell.com
Glypican-3 (GPC3) is a well-characterized hepatocellular carcinoma (HCC)-associated
antigen, yet anti-GPC3 therapies have achieved only minimal clinical progress. CD47 is a …
antigen, yet anti-GPC3 therapies have achieved only minimal clinical progress. CD47 is a …
[HTML][HTML] EpCAM-high liver cancer stem cells resist natural killer cell–mediated cytotoxicity by upregulating CEACAM1
Background Natural killer (NK) cells can recognize and kill cancer cells directly, but their
activity can be attenuated by various inhibitory molecules expressed on the surface. The …
activity can be attenuated by various inhibitory molecules expressed on the surface. The …
[HTML][HTML] Safety and efficacy of sintilimab and anlotinib as first line treatment for advanced hepatocellular carcinoma (KEEP-G04): a single-arm phase 2 study
Purpose: Immune checkpoint inhibitors plus antiangiogenic tyrosine kinase inhibitors may
offer a first-line treatment for advanced hepatocellular carcinoma (HCC). In this phase 2 trial …
offer a first-line treatment for advanced hepatocellular carcinoma (HCC). In this phase 2 trial …
Neutrophil-mediated mechanisms of damage and in-vitro protective effect of colchicine in non-vascular Behçet's syndrome
A Bettiol, M Becatti, E Silvestri… - Clinical & …, 2021 - academic.oup.com
Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …
[HTML][HTML] Intratumor regulatory noncytotoxic NK cells in patients with hepatocellular carcinoma
A Zecca, V Barili, D Rizzo, A Olivani, E Biasini… - Cells, 2021 - mdpi.com
Previous studies support the role of natural killer (NK) cells in controlling hepatocellular
carcinoma (HCC) progression. However, ambiguity remains about the multiplicity and the …
carcinoma (HCC) progression. However, ambiguity remains about the multiplicity and the …
[HTML][HTML] Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells
MA Polidoro, J Mikulak, V Cazzetta, A Lleo… - World journal of …, 2020 - ncbi.nlm.nih.gov
In the last years, several studies have been focused on elucidate the role of tumor
microenvironment (TME) in cancer development and progression. Within TME, cells from …
microenvironment (TME) in cancer development and progression. Within TME, cells from …
[HTML][HTML] Radioembolization for the treatment of hepatocellular carcinoma
HC Kim - Clinical and molecular hepatology, 2017 - ncbi.nlm.nih.gov
Transarterial radioembolization (TARE) with yttrium 90 (90 Y), an intra-arterial procedure
performed by interventional radiologists, has begun being utilized in managing …
performed by interventional radiologists, has begun being utilized in managing …