Differential gene expression gives rise to the many cell types of complex organisms.
Enhancers regulate transcription by binding transcription factors (TFs), which in turn recruit …

Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

Gene regulatory elements are central drivers of phenotypic variation and thus of critical
importance towards understanding the genetics of complex traits. The Functional Annotation …

The mammalian radiation has corresponded with rapid changes in noncoding regions of the
genome, but we lack a comprehensive understanding of regulatory evolution in mammals …

Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-
seq) has become a valuable and widely used approach for mapping the genomic location of …

Genomic enhancers are important regulators of gene expression, but their identification is a
challenge, and methods depend on indirect measures of activity. We developed a method …

The evolution of body shape is thought to be tightly coupled to changes in regulatory
sequences, but specific molecular events associated with major morphological transitions in …

Chromatin accessibility is integral to the process by which transcription factors (TFs) read out
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …

Summary cis-regulatory changes play a central role in morphological divergence, yet the
regulatory principles underlying emergence of human traits remain poorly understood. Here …

Gene activation requires the cooperative activity of multiple transcription factors at cis-
regulatory elements (CREs). Yet, most transcription factors have short residence time …