Prostate cancer (PC) is a leading cause of death in men. Inflammation is one of the initiating
processes whereby cells are trafficked into the tumor microenvironment by specific cytokines …

Advanced prostate cancer is a classic example of the intractability and consequent lethality
that characterizes metastatic carcinomas. Novel treatments have improved the survival of …

Simple Summary Although epithelial-to-mesenchymal transition (EMT) is a well-known
cellular process involved during normal embryogenesis and wound healing, it also has a …

Tumor cells require increased rates of cell metabolism to generate the macromolecules
necessary to sustain proliferation. They rely heavily on NAD+ as a cofactor for multiple …

Notch signaling has been reported to play an essential role in tumorigenesis. Several
studies have suggested that Notch receptors could be oncoproteins or tumor suppressors in …

Although Notch signaling is deregulated in prostate cancer, the role of this pathway in
disease development and progression is not fully understood. Here, we analyzed 2 human …

Despite achieving optimal initial responses to androgen deprivation therapy, most patients
with prostate cancer eventually progress to a poor prognosis state known as castration …

Prostate cancer (PC) is the second most frequently diagnosed cancer and the fifth leading
cause of cancer-related deaths in male population worldwide. Since the growth and …

The role of cyclins in hormone-dependent neoplasms is crucial in the development of the
disease that is resistant to first-line therapy, as the example of breast cancer shows …

Several studies have investigated the role of inflammation in promoting tumorigenesis and
cancer progression. Neoplastic as well as surrounding stromal and inflammatory cells …