Skeletal infections: microbial pathogenesis, immunity and clinical management

EA Masters, BF Ricciardi, KLM Bentley… - Nature Reviews …, 2022 - nature.com
Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many
organisms are linked to skeletal infections, Staphylococcus aureus remains the most …

Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”,“the immune proteome” and “local antibiotic therapy”

EA Masters, RP Trombetta, KL de Mesy Bentley… - Bone research, 2019 - nature.com
Osteomyelitis is a devastating disease caused by microbial infection of bone. While the
frequency of infection following elective orthopedic surgery is low, rates of reinfection are …

Staphylococcal osteomyelitis: disease progression, treatment challenges, and future directions

N Kavanagh, EJ Ryan, A Widaa, G Sexton… - Clinical microbiology …, 2018 - Am Soc Microbiol
Osteomyelitis is an inflammatory bone disease that is caused by an infecting microorganism
and leads to progressive bone destruction and loss. The most common causative species …

Staphylococcal manipulation of host immune responses

V Thammavongsa, HK Kim, D Missiakas… - Nature Reviews …, 2015 - nature.com
Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent
cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is …

Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus

TJ Foster, JA Geoghegan, VK Ganesh… - Nature reviews …, 2014 - nature.com
Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes
about 20% of the human population. Its surface is' decorated'with proteins that are covalently …

Pathogenesis of Staphylococcus aureus Bloodstream Infections

L Thomer, O Schneewind… - Annual Review of …, 2016 - annualreviews.org
Staphylococcus aureus, a Gram-positive bacterium colonizing nares, skin, and the
gastrointestinal tract, frequently invades the skin, soft tissues, and bloodstreams of humans …

Staphylococcal adhesion and host cell invasion: fibronectin-binding and other mechanisms

J Josse, F Laurent, A Diot - Frontiers in microbiology, 2017 - frontiersin.org
Opportunistic bacteria from the genus Staphylococcus can cause life-threatening infections
such as pneumonia, endocarditis, bone and joint infections, and sepsis. This pathogenicity …

Intracellular Staphylococcus aureus: live-in and let die

M Fraunholz, B Sinha - Frontiers in cellular and infection microbiology, 2012 - frontiersin.org
Staphylococcus aureus uses a plethora of virulence factors to accommodate a diversity of
niches in its human host. Aside from the classical manifestations of S. aureus-induced …

Mechanisms of Immune Evasion and Bone Tissue Colonization That Make Staphylococcus aureus the Primary Pathogen in Osteomyelitis

G Muthukrishnan, EA Masters, JL Daiss… - Current osteoporosis …, 2019 - Springer
Abstract Purpose of Review Staphylococcus aureus is the primary pathogen responsible for
osteomyelitis, which remains a major healthcare burden. To understand its dominance, here …

The Multivalent Role of Fibronectin-Binding Proteins A and B (FnBPA and FnBPB) of Staphylococcus aureus in Host Infections

P Speziale, G Pietrocola - Frontiers in microbiology, 2020 - frontiersin.org
Staphylococcus aureus, one of the most important human pathogens, is the causative agent
of several infectious diseases including sepsis, pneumonia, osteomyelitis, endocarditis and …