Opioid use disorder (OUD) is a chronic, relapsing condition, often associated with legal,
interpersonal, and employment problems. Medications demonstrated to be effective for OUD …

Background Opioid dependence is associated with substantial health and social burdens,
and opioid agonist treatment (OAT) is highly effective in improving multiple outcomes for …

Illicit use of opiates is the fastest growing substance use problem in the United States, and
the main reason for seeking addiction treatment services for illicit drug use throughout the …

Background Buprenorphine maintenance treatment has been evaluated in randomised
controlled trials against placebo medication, and separately as an alternative to methadone …

Background Methadone, a full mu-opioid agonist, is the recommended treatment for opioid
dependence during pregnancy. However, prenatal exposure to methadone is associated …

Objective: Extensive exposure to prescription-type opioids has resulted in major harm
worldwide, calling for better-adapted approaches to opioid agonist therapy. The authors …

Background Buprenorphine is a partial µ-opioid receptor agonist used for maintenance
treatment of opioid dependence. Because of the partial agonism and high receptor affinity, it …

AIM: To summarize the major findings of the five Cochrane reviews on substitution
maintenance treatments for opioid dependence. METHODS: We conducted a narrative and …

The present study compared methadone maintenance alone to methadone maintenance in
combination with 16 weeks of either Intensive Twelve-Step Facilitation (ITSF) or Acceptance …

Buprenorphine is a semi-synthetic opioid derived from thebaine, a naturally occurring
alkaloid of the opium poppy, Papaver somniferum. The pharmacology of buprenorphine is …