Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise
F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
Exploration and development of PPAR modulators in health and disease: an update of clinical evidence
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the
expression of genes responsible for energy metabolism, cellular development, and …
expression of genes responsible for energy metabolism, cellular development, and …
Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome
B Kim, EL Feldman - Experimental & molecular medicine, 2015 - nature.com
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that includes obesity,
diabetes, and dyslipidemia. Accumulating evidence implies that MetS contributes to the …
diabetes, and dyslipidemia. Accumulating evidence implies that MetS contributes to the …
The Alzheimer's disease neuroimaging initiative 2 PET core: 2015
Introduction This article reviews the work done in the Alzheimer's Disease Neuroimaging
Initiative positron emission tomography (ADNI PET) core over the past 5 years, largely …
Initiative positron emission tomography (ADNI PET) core over the past 5 years, largely …
Positron emission tomography molecular imaging for drug development
Human in vivo molecular imaging with positron emission tomography (PET) enables a new
kind of 'precision pharmacology', able to address questions central to drug development …
kind of 'precision pharmacology', able to address questions central to drug development …
Genetic mouse models of brain ageing and Alzheimer's disease
A Bilkei-Gorzo - Pharmacology & therapeutics, 2014 - Elsevier
Progression of brain ageing is influenced by a complex interaction of genetic and
environmental factors. Analysis of genetically modified animals with uniform genetic …
environmental factors. Analysis of genetically modified animals with uniform genetic …
What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer's disease, about the therapeutic strategies in Alzheimer's research
M Salkovic-Petrisic, A Knezovic, S Hoyer… - Journal of neural …, 2013 - Springer
Experimental models that faithfully mimic the developmental pathology of sporadic
Alzheimer's disease (sAD) in humans are important for testing the novel therapeutic …
Alzheimer's disease (sAD) in humans are important for testing the novel therapeutic …
Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: Link between type 2 diabetes and Alzheimer's disease
The pathophysiological link between type 2 diabetes mellitus (T2DM) and Alzheimer's
disease (AD) has been suggested in several reports. Few findings suggest that T2DM has …
disease (AD) has been suggested in several reports. Few findings suggest that T2DM has …
PET neuroimaging of Alzheimer's disease: radiotracers and their utility in clinical research
W Bao, F Xie, C Zuo, Y Guan… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's Disease (AD), the leading cause of senile dementia, is a progressive
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …
Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies
Type 2 diabetes mellitus (T2DM) the most prevalent metabolic disease that has evolved into
a major public health issue. Concerning about its secondary complications, a growing body …
a major public health issue. Concerning about its secondary complications, a growing body …