The impact of single and combined PPAR-α and PPAR-γ activation on the neurological outcomes following cerebral ischemia reperfusion

AHF Shehata, ASF Ahmed, AB Abdelrehim, GH Heeba - Life sciences, 2020 - Elsevier
Aim The neuronal damage and accompanied functional deficits induced by cerebral
ischemia are among the most common causes of disabilities in adults. Activation of subtypes …

Pemafibrate prevents retinal neuronal cell death in NMDA-induced excitotoxicity via inhibition of pc-Jun expression

N Fujita, K Sase, C Tsukahara, I Arizono… - Molecular Biology …, 2021 - Springer
Excitotoxicity is involved in the retinal neuronal cell death in diabetic retinopathy. Although
fenofibrate has been shown to ameliorate the progression of diabetic retinopathy, the effect …

Fenofibrate improves cognitive impairment induced by high-fat high-fructose diet: a possible role of Irisin and heat shock proteins

FH Rizk, NA Soliman, NA Heabah… - ACS Chemical …, 2022 - ACS Publications
A high-fat, high-fructose diet (HFFD) impairs cognitive functions and increases susceptibility
to neurodegenerative disorders. Irisin and heat shock protein 70 (HSP70) are well known for …

How cytosolic compartments play safeguard functions against neuroinflammation and cell death in cerebral ischemia

F Ryan, SE Khoshnam, F Khodagholi, G Ashabi… - Metabolic Brain …, 2021 - Springer
Ischemic stroke is the second leading cause of mortality and disability globally. Neuronal
damage following ischemic stroke is rapid and irreversible, and eventually results in …

Exploring biomarkers for ischemic stroke through integrated microarray data analysis

M Lv, W He, T Liang, J Yang, X Huang, S Liu, X Liang… - Brain Research, 2022 - Elsevier
Stroke is the third leading cause of disability-adjusted life years worldwide, and drugs
available for its treatment are limited. This study aimed to explore high-confidence candidate …

Exploring biomarkers and therapeutic targets for ischemic stroke through integrated microarray data analysis

M Lv, W He, T Liang, J Yang, X Huang… - Available at SSRN …, 2021 - papers.ssrn.com
Stroke was the third leading cause of global disability-adjusted life years and its treatment
drugs were limited. Researchers still need to find reliable diagnostic biomarkers and …

[PDF][PDF] Effects of Sofren injection combined with oxygen free radical scavenger on neural function and apoptosis in patients with acute cerebral infarction

JP Feng - Journal of Hainan Medical University, 2019 - scholar.archive.org
Objective: To investigate the effects of Sofren injection combined with oxygen free radical
scavenger on neural function and apoptosis in patients with acute cerebral infarction …

[引用][C] Role of Cav2. 1 Channel Signaling in Glutamate-Related Brain Injury

TY Kim, K Niimi, E Takahashi - Brain Disorder Therapy, 2016