The remarkable capacity of some viruses to adapt to new hosts and environments is highly
dependent on their ability to generate de novo diversity in a short period of time. Rates of …

Viruses survive often harsh host environments, yet we know little about the strategies they
utilize to adapt and subsist given their limited genomic resources. We are beginning to …

Viral infections continue to represent major challenges to public health, and an enhanced
mechanistic understanding of the processes that contribute to viral life cycles is necessary …

Positive-sense RNA viruses encode RNA-dependent RNA polymerases (RdRps) essential
for genomic replication. With the exception of the large nidoviruses, such as coronaviruses …

The emergence of mosquito-borne RNA viruses, such as West Nile virus (WNV), is facilitated
by genetically complex virus populations within hosts. Here, we determine whether WNV …

Mutation rates can evolve through genetic drift, indirect selection due to genetic hitchhiking,
or direct selection on the physicochemical cost of high fidelity. However, for many systems, it …

With next-generation sequencing technologies, it is now feasible to efficiently sequence
patient-derived virus populations at a depth of coverage sufficient to detect rare variants …

Favipiravir is an antiviral agent effective against several RNA viruses. The drug has been
shown to protect mice against experimental infection with a lethal dose of West Nile virus …

We have developed a high-throughput, microfluidics-based platform to perform kinetic
analysis of viral infections in individual cells. We have analyzed thousands of individual …

RNA viruses and viroids replicate with high mutation rates, forming quasispecies, population
of variants centered around dominant sequences. The mechanisms governing quasispecies …