Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Opioid use disorder (OUD) is associated with a high risk of premature death. Medication-
assisted treatment (MAT) is the primary treatment for opioid dependence. We …

Importance Mortality among people with opioid dependence is higher than that of the
general population. Opioid agonist treatment (OAT) is an effective treatment for opioid …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

Stigma as a fundamental hindrance to the United States opioid overdose crisis response |
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Methods| We conducted a retrospective cohort analysis linking data from the Rhode Island
Office of State Medical Examiners for all unintentional deaths from overdose occurring from …

Importance Health profiles and patterns of involvement in the criminal justice system among
people with various levels of opioid use are poorly defined. Data are needed to inform a …

The toll of untreated opioid use disorder is tremendous. In 2015, 33,091 Americans died
from a drug overdose involving an opioid. In just one year, the death rate from heroin …

Federal regulatory changes during the COVID-19 pandemic allow buprenorphine to be
prescribed without an initial in-person evaluation. Prior to COVID-19, numerous barriers …

Background Worldwide opioid-related overdose has become a major public health crisis.
People with opioid use disorder (OUD) are overrepresented in the criminal justice system …