Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of
mortality and age-related diseases in men, but the causal and mechanistic relationships …

Sex differences are present across multiple non-reproductive organ cancers, with male
individuals generally experiencing higher incidence of cancer with poorer outcomes …

Aims Mosaic loss of Y chromosome (LOY) in blood cells is the most common acquired
mutation, increases with age, and is related to cardiovascular disease. Loss of Y …

Genomes are inherently unstable and require constant DNA repair to maintain their genetic
information. However, selective pressure has optimized repair mechanisms in somatic cells …

Background: Genomic instability is a significant hallmark of aging and has a major impact on
aging biology. Mosaic loss of chromosome Y (mLOY) in blood cells is a common …

Background The COVID-19 pandemic, which has a prominent social and economic impact
worldwide, shows a largely unexplained male bias for the severity and mortality of the …

Myelodysplastic syndromes (MDS) are hematological malignancies classically defined by
the presence of cytopenia (s) and dysmorphic myeloid cells. It is now known that MDS can …

BACKGROUND: Mosaic loss of chromosome Y (LOY) is associated with cardiovascular and
neurodegenerative diseases in men, and genetic predisposition to LOY is associated with …

Hematopoietic stem cells (HSCs) are polyfunctional, regenerating all blood cells via
hematopoiesis throughout life. Clonal hematopoiesis (CH) is said to occur when a …