Breast cancer models: Engineering the tumor microenvironment
The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …
development of clinically relevant models to study cancer biology and drug response in …
[HTML][HTML] The extracellular matrix of hematopoietic stem cell niches
C Lee-Thedieck, P Schertl, G Klein - Advanced Drug Delivery Reviews, 2022 - Elsevier
Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …
[HTML][HTML] 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy. Indeed,
several microdevices are being developed specifically for clinical use to test novel cancer …
several microdevices are being developed specifically for clinical use to test novel cancer …
Engineering the pre-metastatic niche
The pre-metastatic niche—the accumulation of aberrant immune cells and extracellular-
matrix proteins in target organs—primes the initially healthy organ microenvironment and …
matrix proteins in target organs—primes the initially healthy organ microenvironment and …
[HTML][HTML] Advanced microfluidic models of cancer and immune cell extravasation: a systematic review of the literature
C Mondadori, M Crippa, M Moretti… - … in bioengineering and …, 2020 - frontiersin.org
Extravasation is a multi-step process implicated in many physiological and pathological
events. This process is essential to get leukocytes to the site of injury or infection but is also …
events. This process is essential to get leukocytes to the site of injury or infection but is also …
Co-culture approaches for cultivated meat production
The need and demand for sustainable, nutritious and animal-welfare-conscious meat
substitutes has spurred research into cultivated meat production. Meat mainly contains …
substitutes has spurred research into cultivated meat production. Meat mainly contains …
Bioprinting and organ-on-chip applications towards personalized medicine for bone diseases
The skeleton supports and confers structure to the whole body but several pathological and
traumatic conditions affect the bone tissue. Most of those pathological conditions are specific …
traumatic conditions affect the bone tissue. Most of those pathological conditions are specific …
3D tissue engineered in vitro models of cancer in bone
AM Sitarski, H Fairfield, C Falank… - … biomaterials science & …, 2018 - ACS Publications
Biological models are necessary tools for gaining insight into underlying mechanisms
governing complex pathologies such as cancer in the bone. Models range from in vitro …
governing complex pathologies such as cancer in the bone. Models range from in vitro …
[HTML][HTML] Controlled tumor heterogeneity in a co-culture system by 3D bio-printed tumor-on-chip model
N Moghimi, SA Hosseini, AB Dalan… - Scientific Reports, 2023 - nature.com
Cancer treatment resistance is a caused by presence of various types of cells and
heterogeneity within the tumor. Tumor cell–cell and cell-microenvironment interactions play …
heterogeneity within the tumor. Tumor cell–cell and cell-microenvironment interactions play …
Multi compartmental 3D breast cancer disease model–recapitulating tumor complexity in in-vitro
Breast cancer is the most common ailment among women. In 2020, it had the highest
incidence of any type of cancer. Many Phase II and III anti-cancer drugs fail due to efficacy …
incidence of any type of cancer. Many Phase II and III anti-cancer drugs fail due to efficacy …