Aging is a major cause of many degenerative diseases. The most intuitive consequence of
aging is mainly manifested on the skin, resulting in cumulative changes in skin structure …

Autophagy is fundamental for cell and organismal health. Two types of autophagy are
conserved in eukaryotes: macroautophagy and microautophagy. During macroautophagy …

Autophagy is the process of cellular self-eating by a double-membrane organelle, the
autophagosome. A range of signaling processes converge on two protein complexes to …

Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

Autophagy is a process of self-degradation that enables the cell to survive when faced with
starvation or stressful conditions. The mechanistic target of rapamycin (mTOR), also known …

Macroautophagic clearance of cytosolic materials entails the initiation, growth and closure of
autophagosomes. Cargo triggers the assembly of a web of cargo receptors and core …

Cellular homeostasis and adaptation to various environmental conditions are importantly
regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling …

Autophagosomes are unique organelles that form de novo as double-membrane vesicles
engulfing cytosolic material for destruction. Their biogenesis involves membrane …

Autophagy is a conserved catabolic homeostasis process central for cellular and organismal
health. During autophagy, small single-membrane phagophores rapidly expand into large …

Autophagy is catabolic process by degradation of intracellular components in lysosome
including proteins, lipids, and mitochondria in response to nutrient deficiency or stress such …