Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …

Many important interactions between bacterial pathogens and their hosts are highly specific
binding events that involve host or pathogen carbohydrate structures (glycans). Glycan …

Through their specific interactions with proteins, cellular glycans play key roles in a wide
range of physiological and pathological processes. One of the main goals of research in the …

Streptococcus pneumoniae is an opportunistic pathogen responsible for widespread illness
and is a major global health issue for children, the elderly, and the immunocompromised …

Bacillus cereus is a Gram-positive bacterium that mainly causes self-limiting emetic or
diarrheal illness but can also cause skin infections and bacteremia. Symptoms of B. cereus …

Summary Group A Streptococcus (Streptococcus pyogenes), group B Streptococcus
(Streptococcus agalactiae) and Streptococcus pneumoniae (pneumococcus) are host …

Listeriolysin O (LLO) is an essential determinant of Listeria monocytogenes pathogenesis
that mediates the escape of L. monocytogenes from host cell vacuoles, thereby allowing …

Streptococcus pneumoniae accounts for more deaths worldwide than any other single
pathogen through diverse disease manifestations including pneumonia, sepsis and …

Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but
cholesterol alone is insufficient to explain their cell and host tropism. Here, we show that all …

Pore-forming toxins (PFTs) are important virulence factors produced by many pathogenic
bacteria. Here, we show that the Vibrio cholerae toxin MakA is a novel cholesterol-binding …