Mitochondrial abnormalities in the brain are considered early pathological changes in
neurogenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD) and …

Parkinson's disease (PD) is characterized by the presence of insoluble protein clusters
containing α-synuclein. Impairment of mitochondria, endoplasmic reticulum, autophagy and …

Excessive mitochondrial fission in podocytes is a critical feature of diabetic nephropathy
(DN). Mitochondria-associated endoplasmic reticulum membranes (MAMs) are contact sites …

Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors have changed the
therapeutic landscape for diabetic kidney disease (DKD) patients, but their underlying …

Selective elimination of mitochondria by autophagy is a critical strategy for a variety of
physiological processes, including development, cell-fate determination and stress …

The liver plays a central role in glucose homeostasis, and both metabolic inflexibility and
insulin resistance predispose to the development of hepatic metabolic diseases …

Aims The main purpose was to verify the potent capacity of Neurotropin® against neuronal
damage in hippocampus and to explore its underlying mechanisms. Methods HT 22 cells …

Mitochondria are the key biological generators of eukaryotic cells, controlling the energy
supply while providing many important biosynthetic intermediates. Mitochondria act as a …

The mitochondrial genome transcribes 13 mRNAs coding for well-known proteins essential
for oxidative phosphorylation. We demonstrate here that cytochrome b (CYTB), the only …

Living organisms have the capacity to sense both nutrients and immune signals in order to
adapt their metabolism to the needs, and both metabolic inflexibility and exacerbated …