Cells in osteoclast and osteoblast lineages communicate with each other through cell–cell
contact, diffusible paracrine factors and cell–bone matrix interaction. Osteoclast–osteoblast …

Much has been written recently on osteoclast biology, but this cell type still astonishes
scientists with its multifaceted functions and unique properties. The last three decades have …

Bone homeostasis requires a delicate balance between the activities of bone-resorbing
osteoclasts and bone-forming osteoblasts. Various molecules coordinate osteoclast function …

Tartrate-resistant acid phosphatase (TRAP), once considered to be just a histochemical
marker of osteoclasts is now recognised to be a molecule of widespread occurrence with …

The reversal phase couples bone resorption to bone formation by generating an osteogenic
environment at remodeling sites. The coupling mechanism remains poorly understood …

Bone remodeling is required for healthy calcium homeostasis and for repair of damage
occurring with stress and age. Osteoclasts resorb bone and osteoblasts form bone. These …

Tartrate-resistant acid phosphatase (TRACP) is an enzyme that is expressed in high
amounts by bone-resorbing osteoclasts, inflammatory macrophages and dendritic cells. Two …

METHODS: To test this hypothesis, we examined the response of several cell models at
various states in the osteoblast lineage to titanium surfaces with smooth and rough …

Some osteopetrotic mutations lead to low resorption, increased numbers of osteoclasts, and
increased bone formation, whereas other osteopetrotic mutations lead to low resorption, low …

Tartrate-resistant acid phosphatase (TRAP) is a metallophosphoesterase participating in
osteoclast-mediated bone turnover. Activation of TRAP is associated with the redox state of …