Ubiquitylation is an essential post-translational modification that regulates intracellular
signalling networks by triggering proteasomal substrate degradation, changing the activity of …

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …

The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …

Damage-associated molecular patterns (DAMPs) are endogenous molecules that are
released from host cells as a result of cell death or damage. The release of DAMPs in …

Mutations in genes coding for proteasome subunits and/or proteasome assembly helpers
typically cause recurring autoinflammation referred to as chronic atypical neutrophilic …

Background Systemic lupus erythematosus (SLE) is an autoimmune illness caused by a
malfunctioning immunomodulatory system. China has the second highest prevalence of SLE …

Neuronal cells are specialists for rapid transfer and translation of information. Their electrical
properties relay on a precise regulation of ion levels while their communication via …

Microglia are the resident immune cells of the central nervous system (CNS) and play a
major role in the regulation of brain homeostasis. To maintain their cellular protein …

Proteotoxic stress, caused by the accumulation of abnormal unfolded or misfolded cellular
proteins, can efficiently activate inflammatory innate immune response. Initiating the …

Early detection of infection is a central and critical component of our innate immune system.
Mammalian cells have developed specialized receptors that detect RNA with unusual …