Disorders of ubiquitylation: unchained inflammation
Ubiquitylation is an essential post-translational modification that regulates intracellular
signalling networks by triggering proteasomal substrate degradation, changing the activity of …
signalling networks by triggering proteasomal substrate degradation, changing the activity of …
DAMPs and DAMP-sensing receptors in inflammation and diseases
M Ma, W Jiang, R Zhou - Immunity, 2024 - cell.com
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …
produced in cellular damage or stress, and they can activate the innate immune system …
Mammalian integrated stress responses in stressed organelles and their functions
H Lu, N Koju, R Sheng - Acta Pharmacologica Sinica, 2024 - nature.com
The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …
DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways
Damage-associated molecular patterns (DAMPs) are endogenous molecules that are
released from host cells as a result of cell death or damage. The release of DAMPs in …
released from host cells as a result of cell death or damage. The release of DAMPs in …
Identification of eight novel proteasome variants in five unrelated cases of proteasome-associated autoinflammatory syndromes (PRAAS)
JJ Papendorf, F Ebstein, S Alehashemi… - Frontiers in …, 2023 - frontiersin.org
Mutations in genes coding for proteasome subunits and/or proteasome assembly helpers
typically cause recurring autoinflammation referred to as chronic atypical neutrophilic …
typically cause recurring autoinflammation referred to as chronic atypical neutrophilic …
Screening biomarkers for systemic lupus erythematosus based on machine learning and exploring their expression correlations with the ratios of various immune cells
Y Zhong, W Zhang, X Hong, Z Zeng, Y Chen… - Frontiers in …, 2022 - frontiersin.org
Background Systemic lupus erythematosus (SLE) is an autoimmune illness caused by a
malfunctioning immunomodulatory system. China has the second highest prevalence of SLE …
malfunctioning immunomodulatory system. China has the second highest prevalence of SLE …
Endoplasmic reticulum stress and its role in homeostasis and immunity of central and peripheral neurons
Neuronal cells are specialists for rapid transfer and translation of information. Their electrical
properties relay on a precise regulation of ion levels while their communication via …
properties relay on a precise regulation of ion levels while their communication via …
Immunoproteasomes control activation of innate immune signaling and microglial function
G Çetin, M Studencka-Turski, S Venz… - Frontiers in …, 2022 - frontiersin.org
Microglia are the resident immune cells of the central nervous system (CNS) and play a
major role in the regulation of brain homeostasis. To maintain their cellular protein …
major role in the regulation of brain homeostasis. To maintain their cellular protein …
Cuproptotic nanoinducer-driven proteotoxic stress potentiates cancer immunotherapy by activating the mtDNA–cGAS–STING signaling
Proteotoxic stress, caused by the accumulation of abnormal unfolded or misfolded cellular
proteins, can efficiently activate inflammatory innate immune response. Initiating the …
proteins, can efficiently activate inflammatory innate immune response. Initiating the …
Activation of cytosolic RNA sensors by endogenous ligands: roles in disease pathogenesis
S Straub, NG Sampaio - Frontiers in Immunology, 2023 - frontiersin.org
Early detection of infection is a central and critical component of our innate immune system.
Mammalian cells have developed specialized receptors that detect RNA with unusual …
Mammalian cells have developed specialized receptors that detect RNA with unusual …