Cholesterol is a multifaceted molecule, which serves as essential membrane component, as
cofactor for signaling molecules and as precursor for steroid hormones. Consequently …

The formation of lateral microdomains is emerging as a central organizing principle in
bacterial membranes. These microdomains are targets of antibiotic development and have …

Cholesterol plays an important role in determining the biophysical properties of biological
membranes, and its concentration is tightly controlled by homeostatic processes. The …

Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the
distribution of cellular cholesterol is associated with numerous diseases, including …

NPC1L1, a recently identified relative of Niemann-Pick C1, was characterized to determine
its subcellular location and potential function (s). NPC1L1 was highly expressed in HepG2 …

Analogues of cholesterol (compounds 1 and 2) and coprostanol (compound 3) containing
the BODIPY fluorophore in the aliphatic tail of the free sterol have been synthesized starting …

▪ Abstract Current models for cellular plasma membranes focus on spatial heterogeneity and
how this heterogeneity relates to cell function. In particular, putative lipid raft membrane …

Coupling atomic force microscopy (AFM) with high-resolution fluorescence microscopy is an
attractive means of identifying membrane domains by both physical topography and …

Neurotransmitter release from sympathetic terminals is a key avenue for heart regulation.
Herein, presynaptic exocytotic activity was monitored in mice atrial tissue using a false …

Lipid rafts in eukaryotic cells are sphingolipid and cholesterol-rich, ordered membrane
regions that have been postulated to play roles in many membrane functions, including …