Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the
patients′ capacity for daily functioning. Whereas our understanding of its pathophysiology …

Cellular compartments that cannot be biochemically isolated are challenging to
characterize. Here we demonstrate the proteomic characterization of the synaptic clefts that …

We recently described a severe, potentially lethal, but treatment-responsive encephalitis that
associates with autoantibodies to the NMDA receptor (NMDAR) and results in behavioral …

Consistent with recent reports indicating that neurons differentiated in vitro from human-
induced pluripotent stem cells (hiPSCs) are immature relative to those in the human brain …

Schizophrenia is a complex disorder that interferes with the function of several brain systems
required for cognition and normal social behaviour. Although the most notable clinical …

Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …

We used data from studies of copy-number variants (CNVs), single-gene associations,
growth-signaling pathways, and intermediate phenotypes associated with brain growth to …

Heat perception enables acute avoidance responses to prevent tissue damage and
maintain body thermal homeostasis. Unlike other modalities, how heat signals are …

Neuregulin 1 (NRG1) and its receptor ErbB4 are both susceptibility genes of schizophrenia.
However, little is known about the underlying mechanisms of their malfunction. Although …