Developing recombinant antibodies by phage display against infectious diseases and toxins for diagnostics and therapy

KDR Roth, EV Wenzel, M Ruschig, S Steinke… - Frontiers in cellular …, 2021 - frontiersin.org
Antibodies are essential molecules for diagnosis and treatment of diseases caused by
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …

Anti-CTLA-4 nanobody as a promising approach in cancer immunotherapy

M Babamohamadi, N Mohammadi, E Faryadi… - Cell Death & …, 2024 - nature.com
Cancer is one of the most common diseases and causes of death worldwide. Since common
treatment approaches do not yield acceptable results in many patients, developing …

Portable, on-demand biomolecular manufacturing

K Pardee, S Slomovic, PQ Nguyen, JW Lee, N Donghia… - Cell, 2016 - cell.com
Synthetic biology uses living cells as molecular foundries for the biosynthesis of drugs,
therapeutic proteins, and other commodities. However, the need for specialized equipment …

Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies

MH Abdolvahab, P Karimi, N Mohajeri, M Abedini… - Cancer Cell …, 2024 - Springer
Targeted drug delivery is one of the attractive ways in which cancer treatment can
significantly reduce side effects. In the last two decades, the use of antibodies as a tool for …

Phage‐based technologies for highly sensitive luminescent detection of foodborne pathogens and microbial toxins: A review

J Ye, J Guo, T Li, J Tian, M Yu, X Wang… - … Reviews in Food …, 2022 - Wiley Online Library
Foodborne pathogens and microbial toxins are the main causes of foodborne illness.
However, trace pathogens and toxins in foods are difficult to detect. Thus, techniques for …

Nanobodies: The potential application in bacterial treatment and diagnosis

S Yu, L Zhang, A Wang, Y Jin, D Zhou - Biochemical Pharmacology, 2023 - Elsevier
An infection caused by bacteria is one of the main factors that poses a threat to human
health. A recent report from the World Health Organization (WHO) has highlighted that …

Bacteriophage vehicles for phage display: biology, mechanism, and application

W Ebrahimizadeh, M Rajabibazl - Current microbiology, 2014 - Springer
The phage display technique is a powerful tool for selection of various biological agents.
This technique allows construction of large libraries from the antibody repertoire of different …

Isolation of bactrian camel single domain antibody for parathion and development of one-step dc-FEIA method using VHH-alkaline phosphatase fusion protein

YQ Zhang, ZL Xu, F Wang, J Cai, JX Dong… - Analytical …, 2018 - ACS Publications
A heavy chain variable fragment of heavy chain only antibodies derived from camelids
termed VHH shows beneficial characteristics for immunoassay in terms of high sensitivity …

Nanobodies: A tool to open new horizons in diagnosis and treatment of prostate cancer

M Hosseindokht, H Bakherad, H Zare - Cancer Cell International, 2021 - Springer
Background Prostate cancer is one of the most common cancers in men and its incidence
has increased dramatically in the last decade. This increase in the detection of this type of …

Preparation of a nanobody specific to dectin 1 and its anti-inflammatory effects on fungal keratitis

X Liu, J Sui, C Li, X Peng, Q Wang, N Jiang… - International Journal …, 2022 - Taylor & Francis
Objective To prepare a nanobody specific to dectin 1 and verify its specificity and anti-
inflammatory effects on Aspergillus fumigatus keratitis. Methods The nanobody was selected …