A major goal of hemoglobinopathy research is to develop treatments that correct the
underlying molecular defects responsible for sickle cell disease and β-thalassemia. One …

Introduction: Stress erythropoiesis induces fetal hemoglobin (HbF) expression in β-
thalassemias, however the level of expression is highly variable. The last decade has seen …

Objective: To summarize recently published data on the pathophysiology, diagnosis and
treatment of sickle cell diseases and β-Thalassemias, the most relevant hereditary …

The rare PEL-negative phenotype is one of the last blood groups with an unknown genetic
basis. By combining whole-exome sequencing and comparative global proteomic …

Therapeutic regulation of globin genes is a primary goal of translational research aimed
toward hemoglobinopathies. Signal transduction was used to identify chromatin …

Reactivation of fetal hemoglobin (HbF) in adult hematopoietic cells has the potential for
great clinical benefit in patients bearing deleterious mutations in the β-globin gene, such as …

Summary β‐thalassaemia is one of the most common inherited anaemias, arising from a
partial or complete loss of β‐globin chain synthesis. In severe cases, marked bone marrow …

Much attention has been directed to the physiological effects of nitric oxide (NO)-cGMP
signaling, but virtually nothing is known about its hematologic effects. We reported for the …

Aim: In this study we explored the association between genetic variations in MAP3K5 and
PDE7B genes, residing on chromosome 6q23, and disease severity in β-hemoglobinopathy …

Anemia is a common pathophysiological response to stressors, malnutrition and infections
in salmonid fish. In order to improve our understanding of the molecular mechanisms and …