The nucleosome remodelling and histone deacetylase (NuRD; also known as Mi-2) complex
regulates gene expression at the level of chromatin. The NuRD complex has been identified …

Cancer cells frequently exhibit deregulation of coregulatory molecules to drive the process
of growth and metastasis. One such group of ubiquitously expressed coregulators is the …

The MTA1 protein contributes to the process of cancer progression and metastasis through
multiple genes and protein targets and interacting proteins with roles in transformation …

Background: A 28 amino-acid (aa) cell-penetrating peptide (p28) derived from azurin, a
redox protein secreted from the opportunistic pathogen Pseudomonas aeruginosa …

Metastatic associated proteins (MTA) are integrators of upstream regulatory signals with the
ability to act as master coregulators for modifying gene transcriptional activity. The MTA …

Background SALL1 is a multi-zinc finger transcription factor that regulates organogenesis
and stem cell development, but the role of SALL1 in tumor biology and tumorigenesis …

Tumor suppressor p53 prevents tumorigenesis by promoting cell cycle arrest and apoptosis
through transcriptional regulation. Dysfunction of p53 occurs frequently in human cancers …

Common workflows in bottom-up proteomics require homogenization of tissue samples to
gain access to the biomolecules within the cells. The homogenized tissue samples often …

The progression to advanced stage cancer requires changes in many characteristics of a
cell. These changes are usually initiated through spontaneous mutation. As a result of these …

Although the functional significance of the metastasic tumor antigen (MTA) family of
chromatin remodeling proteins in the pathobiology of cancer is fairly well recognized, the …