Poly (ADP-ribosylation) is a post-translational modification of proteins playing a crucial role
in many processes, including DNA repair and cell death. The best known poly (ADP …

Etoposide is a potent anti-tumor drug that belongs to the class of topoisomerase poisons.
Although its molecular target, ie DNA topoisomerase II, has been identified more than 20 …

Caspase-mediated cleavage of PARP1 is a surrogate marker for apoptosis. However, the
biological significance of PARP1 cleavage during apoptosis is still unclear. Here, using …

The cleavage of nuclear proteins by caspases promotes nuclear breakdown and, therefore,
plays a key role in apoptosis execution. However, the detailed molecular mechanisms of …

Molecular defects in apoptotic pathways are thought to often contribute to the abnormal
expansion of malignant cells and their resistance to chemotherapy. Therefore, a …

Poly (ADP-ribosylation) is a post-translational modification of proteins playing a crucial role
in DNA repair, replication, transcription and cell death. In this paper, the main features of this …

Cellular senescence is described to be a consequence of telomere erosion during the
replicative life span of primary human cells. Quiescence should therefore not contribute to …

Background The vast majority of oocytes formed in the fetal ovary do not survive beyond
birth. Possible reasons for their loss include the elimination of non-viable genetic …

Enteropathogenic Escherichia coli (EPEC) has the ability to antagonize host apoptosis
during infection through promotion and inhibition of effectors injected by the type III secretion …

The human immunodeficiency virus type-1 (HIV-1) accessory gene vpr encodes a
conserved 96-amino-acid protein that is necessary and sufficient for the HIV-1-induced block …