Obesity is a major risk factor for metabolic disease, with white adipose tissue (WAT)
inflammation emerging as a key underlying pathology. Alongside its major role in energy …

Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …

Dedifferentiation‐associated inflammatory factors of long‐te... : Hepatology Dedifferentiation‐associated
inflammatory factors of long‐term expanded human hepatocytes exacerbate their elimination …

Immunologically based clinical trials performed thus far have failed to cure type 1 diabetes
(T1D), in part because these approaches were nonspecific. Because the disease is driven …

We show here that human pancreatic islets highly express C3, which is both secreted and
present in the cytosol. Within isolated human islets, C3 expression correlates with type 2 …

Diabetes mellitus results from immune cell invasion into pancreatic islets of Langerhans,
eventually leading to selective destruction of the insulin-producing β-cells. How this process …

Cell encapsulation has already shown its high potential and holds the promise for future cell
therapies to enter the clinics as a large scale treatment option for various types of diseases …

The human pancreas, like almost all organs in the human body, is immunologically tolerated
despite the presence of innate and adaptive immune cells that promptly mediate protective …

Islet transplantation represents a potentially curative approach for individuals with Type I
Diabetes. The requirement for systemic immune suppression to control immune-mediated …

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Previous
studies have shown that inflammatory chemokines are involved in the physiological …