The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …

The nuclear events of a eukaryotic cell, such as replication, transcription, recombination and
repair etc. require the transition of the compactly arranged chromatin into an uncompacted …

Transient stress experiences not only trigger acute stress responses, but can also have long-
lasting effects on cellular functions. In Caenorhabditis elegans, a brief exposure to heat …

The transition from proliferating precursor cells to post-mitotic differentiated cells is crucial for
development, tissue homeostasis, and tumor suppression. To study cell-cycle exit during …

Chromatin remodelers such as the SWI/SNF complex coordinate metazoan development
through broad regulation of chromatin accessibility and transcription, ensuring normal cell …

Alcohol abuse is a widespread and serious problem. Understanding the factors that
influence the likelihood of abuse is important for the development of effective therapies …

SWItch/sucrose non-fermenting (SWI/SNF) complexes are a family of chromatin remodelers
that are conserved across eukaryotes. Mutations in subunits of SWI/SNF cause a multitude …

Background SWI/SNF chromatin remodeling genes are required for normal acute responses
to alcohol in C. elegans and are associated with alcohol use disorder in two human …

The Caenorhabditis elegans somatic gonadal precursors (SGPs) are multipotent progenitors
that generate all somatic cells of the adult reproductive system. The 2 SGPs originate in the …

Bromodomains (BD) are conserved reader modules that bind acetylated lysine residues on
histones. Although much has been learned regarding the in vitro properties of these …