Diseases caused by mutations in ORAI1 and STIM1
Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
Ion channels in innate and adaptive immunity
Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …
Vaccine adjuvants to engage the cross-presentation pathway
Adjuvants are indispensable components of vaccines for stimulating optimal immune
responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral …
responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral …
Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation
The application of current channelrhodopsin-based optogenetic tools is limited by the lack of
strict ion selectivity and the inability to extend the spectra sensitivity into the near-infrared …
strict ion selectivity and the inability to extend the spectra sensitivity into the near-infrared …
What is the evidence for the role of TRP channels in inflammatory and immune cells?
A complex network of many interacting mechanisms orchestrates immune and inflammatory
responses. Among these, the cation channels of the transient receptor potential (TRP) family …
responses. Among these, the cation channels of the transient receptor potential (TRP) family …
Ca2+ signaling but not store-operated Ca2+ entry is required for the function of macrophages and dendritic cells
Abstract Store-operated Ca 2+ entry (SOCE) through Ca 2+ release–activated Ca 2+(CRAC)
channels is essential for immunity to infection. CRAC channels are formed by ORAI1 …
channels is essential for immunity to infection. CRAC channels are formed by ORAI1 …
STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror Diseases
Store-operated Ca2+ entry (SOCE) is a ubiquitous and essential mechanism regulating
Ca2+ homeostasis in all tissues, and controls a wide range of cellular functions including …
Ca2+ homeostasis in all tissues, and controls a wide range of cellular functions including …
[HTML][HTML] The role of transient receptor potential channels in metastasis
S Bai, Y Wei, R Liu, Y Chen, W Ma, M Wang… - Biomedicine & …, 2023 - Elsevier
Metastasis is the hallmark of failed tumor treatment and is typically associated with death
due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular …
due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular …
The role of STIM and ORAI proteins in phagocytic immune cells
N Demaurex, P Nunes - American Journal of Physiology …, 2016 - journals.physiology.org
Phagocytic cells, such as neutrophils, macrophages, and dendritic cells, migrate to sites of
infection or damage and are integral to innate immunity through two main mechanisms. The …
infection or damage and are integral to innate immunity through two main mechanisms. The …
STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells
P Nunes-Hasler, S Maschalidi, C Lippens… - Nature …, 2017 - nature.com
Antigen cross-presentation by dendritic cells (DC) stimulates cytotoxic T cell activation to
promote immunity to intracellular pathogens, viruses and cancer. Phagocytosed antigens …
promote immunity to intracellular pathogens, viruses and cancer. Phagocytosed antigens …