Tools and strategies of systems metabolic engineering for the development of microbial cell factories for chemical production
Sustainable production of chemicals from renewable non-food biomass has become a
promising alternative to overcome environmental issues caused by our heavy dependence …
promising alternative to overcome environmental issues caused by our heavy dependence …
Designing microbial cell factories for the production of chemicals
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …
as an essential alternative to address pressing environmental issues arising from our heavy …
Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism
Through advanced mechanistic modeling and the generation of large high-quality datasets,
machine learning is becoming an integral part of understanding and engineering living …
machine learning is becoming an integral part of understanding and engineering living …
Synthetic biology strategies for microbial biosynthesis of plant natural products
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …
[HTML][HTML] A field of dreams: Lignin valorization into chemicals, materials, fuels, and health-care products
J Becker, C Wittmann - Biotechnology Advances, 2019 - Elsevier
Lignin is one of the most abundant renewable resources on earth and is readily produced as
a sidestream during biomass fractioning. So far, these large quantities of lignin have been …
a sidestream during biomass fractioning. So far, these large quantities of lignin have been …
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals
The microbial production of fine chemicals provides a promising biosustainable
manufacturing solution that has led to the successful production of a growing catalog of …
manufacturing solution that has led to the successful production of a growing catalog of …
Synthetic biology—the synthesis of biology
S Ausländer, D Ausländer… - Angewandte Chemie …, 2017 - Wiley Online Library
Synthetic biology concerns the engineering of man‐made living biomachines from
standardized components that can perform predefined functions in a (self‐) controlled …
standardized components that can perform predefined functions in a (self‐) controlled …
EcoFlex: A Multifunctional MoClo Kit for E. coli Synthetic Biology
Golden Gate cloning is a prominent DNA assembly tool in synthetic biology for the assembly
of plasmid constructs often used in combinatorial pathway optimization, with a number of …
of plasmid constructs often used in combinatorial pathway optimization, with a number of …
Towards next-generation cell factories by rational genome-scale engineering
Metabolic engineering holds the promise to transform the chemical industry and to support
the transition into a circular bioeconomy, by engineering cellular biocatalysts that efficiently …
the transition into a circular bioeconomy, by engineering cellular biocatalysts that efficiently …
Promoter-Library-Based Pathway Optimization for Efficient (2S)-Naringenin Production from p-Coumaric Acid in Saccharomyces cerevisiae
Pathway optimization plays an important role in fine-tuning metabolic pathways. In most
conditions, more than three genes are involved in the biosynthesis pathway of a specific …
conditions, more than three genes are involved in the biosynthesis pathway of a specific …