Cellular functions and molecular mechanisms of the ESCRT membrane-scission machinery
L Christ, C Raiborg, EM Wenzel, C Campsteijn… - Trends in biochemical …, 2017 - cell.com
The endosomal sorting complex required for transport (ESCRT) machinery is an assembly of
protein subcomplexes (ESCRT I-III) that cooperate with the ATPase VPS4 to mediate …
protein subcomplexes (ESCRT I-III) that cooperate with the ATPase VPS4 to mediate …
[HTML][HTML] Biological activities of extracellular vesicles and their cargos from bovine and human milk in humans and implications for infants
Extracellular vesicles (EVs) in milk harbor a variety of compounds, including lipids, proteins,
noncoding RNAs, and mRNAs. Among the various classes of EVs, exosomes are of …
noncoding RNAs, and mRNAs. Among the various classes of EVs, exosomes are of …
Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19
X Bi, W Liu, X Ding, S Liang, Y Zheng, X Zhu, S Quan… - Cell reports, 2022 - cell.com
The utility of the urinary proteome in infectious diseases remains unclear. Here, we analyzed
the proteome and metabolome of urine and serum samples from patients with COVID-19 …
the proteome and metabolome of urine and serum samples from patients with COVID-19 …
Multivesicular body morphogenesis
PI Hanson, A Cashikar - Annual review of cell and …, 2012 - annualreviews.org
Multivesicular bodies (MVBs) are unique organelles in the endocytic pathway that contain
vesicles in their lumen. Sorting and incorporation of material into such vesicles is a critical …
vesicles in their lumen. Sorting and incorporation of material into such vesicles is a critical …
[HTML][HTML] Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease
SM Migliano, EM Wenzel, H Stenmark - Current opinion in cell biology, 2022 - Elsevier
The endosomal sorting complex required for transport (ESCRT) machinery evolved early in
evolution to sculpt and cut cellular membranes. Consisting of three subcomplexes termed …
evolution to sculpt and cut cellular membranes. Consisting of three subcomplexes termed …
Exosomal biomarkers for cancer diagnosis and patient monitoring
Introduction: In recent years, extensive research has been conducted on using exosomes as
biomarkers for cancer detection. Exosomes are 40–150 nm-sized extracellular vesicles …
biomarkers for cancer detection. Exosomes are 40–150 nm-sized extracellular vesicles …
PI (3, 4) P2-mediated cytokinetic abscission prevents early senescence and cataract formation
INTRODUCTION In response to aging, senescence plays a major role in the onset of various
degenerative diseases, including the slow development of cataracts, a clouding of the eye …
degenerative diseases, including the slow development of cataracts, a clouding of the eye …
An extended proteome map of the lysosomal membrane reveals novel potential transporters
A Chapel, S Kieffer-Jaquinod, C Sagne… - Molecular & Cellular …, 2013 - ASBMB
Lysosomes are membrane-bound endocytic organelles that play a major role in degrading
cell macromolecules and recycling their building blocks. A comprehensive knowledge of the …
cell macromolecules and recycling their building blocks. A comprehensive knowledge of the …
Cellular functions of the DUBs
Ubiquitylation is a reversible post-translational modification that has emerged as a key
regulator of most complex cellular processes. It may rival phosphorylation in scope and …
regulator of most complex cellular processes. It may rival phosphorylation in scope and …
Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation
Five endosomal sorting complexes required for transport (ESCRTs) mediate the degradation
of ubiquitinated membrane proteins via multivesicular bodies (MVBs) in lysosomes. ESCRT …
of ubiquitinated membrane proteins via multivesicular bodies (MVBs) in lysosomes. ESCRT …