Pulmonary innate immune response determines the outcome of inflammation during pneumonia and sepsis-associated acute lung injury

V Kumar - Frontiers in immunology, 2020 - frontiersin.org
The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

Air pollution and its effects on the immune system

DA Glencross, TR Ho, N Camina… - Free Radical Biology …, 2020 - Elsevier
A well-functioning immune system is vital for a healthy body. Inadequate and excessive
immune responses underlie diverse pathologies such as serious infections, metastatic …

NLRP3 inflammasome and the IL-1 pathway in atherosclerosis

A Grebe, F Hoss, E Latz - Circulation research, 2018 - Am Heart Assoc
Inflammation is an important driver of atherosclerosis, the underlying pathology of
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …

Cross-talk between alveolar macrophages and lung epithelial cells is essential to maintain lung homeostasis

EY Bissonnette, JF Lauzon-Joset, JS Debley… - Frontiers in …, 2020 - frontiersin.org
The main function of the lung is to perform gas exchange while maintaining lung
homeostasis despite environmental pathogenic and non-pathogenic elements contained in …

SARS‐CoV‐2 infection, COVID‐19 pathogenesis, and exposure to air pollution: What is the connection?

B Woodby, MM Arnold… - Annals of the new York …, 2021 - Wiley Online Library
Exposure to air pollutants has been previously associated with respiratory viral infections,
including influenza, measles, mumps, rhinovirus, and respiratory syncytial virus …

Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

LQ Wang, T Liu, S Yang, L Sun, ZY Zhao, LY Li… - Nature …, 2021 - nature.com
Perfluoroalkyl substances (PFAS) are widely used in various manufacturing processes.
Accumulation of these chemicals has adverse effects on human health, including …

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

Y Yue, NR Nabar, CS Shi, O Kamenyeva, X Xiao… - Cell death & …, 2018 - nature.com
The molecular mechanisms underlying the severe lung pathology that occurs during SARS-
CoV infections remain incompletely understood. The largest of the SARS-CoV accessory …

The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases

M Sayan, BT Mossman - Particle and fibre toxicology, 2015 - Springer
The concept of the inflammasome, a macromolecular complex sensing cell stress or danger
signals and initiating inflammation, was first introduced approximately a decade ago …

Elevated expression of the NLRP3 inflammasome in neutrophilic asthma

JL Simpson, S Phipps, KJ Baines… - European …, 2014 - Eur Respiratory Soc
Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1β is
thought to be a key mediator, especially in the neutrophilic subtype of asthma. The …

Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiome

L Kish, N Hotte, GG Kaplan, R Vincent, R Tso… - PloS one, 2013 - journals.plos.org
Background Particulate matter (PM) is a key pollutant in ambient air that has been
associated with negative health conditions in urban environments. The aim of this study was …