[HTML][HTML] Tendon injury and repair–A perspective on the basic mechanisms of tendon disease and future clinical therapy
JG Snedeker, J Foolen - Acta biomaterialia, 2017 - Elsevier
Tendon is an intricately organized connective tissue that efficiently transfers muscle force to
the bony skeleton. Its structure, function, and physiology reflect the extreme, repetitive …
the bony skeleton. Its structure, function, and physiology reflect the extreme, repetitive …
The chemistry and biology of collagen hybridization
X Li, Q Zhang, SM Yu, Y Li - Journal of the American Chemical …, 2023 - ACS Publications
Collagen provides mechanical and biological support for virtually all human tissues in the
extracellular matrix (ECM). Its defining molecular structure, the triple-helix, could be …
extracellular matrix (ECM). Its defining molecular structure, the triple-helix, could be …
[HTML][HTML] Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides
Mechanical injury to connective tissue causes changes in collagen structure and material
behaviour, but the role and mechanisms of molecular damage have not been established. In …
behaviour, but the role and mechanisms of molecular damage have not been established. In …
Accumulation of collagen molecular unfolding is the mechanism of cyclic fatigue damage and failure in collagenous tissues
Overuse injuries to dense collagenous tissues are common, but their etiology is poorly
understood. The predominant hypothesis that micro-damage accumulation exceeds the rate …
understood. The predominant hypothesis that micro-damage accumulation exceeds the rate …
Collagen fibrils in functionally distinct tendons have differing structural responses to tendon rupture and fatigue loading
In this study we investigate relationships between the nanoscale structure of collagen fibrils
and the macroscale functional response of collagenous tissues. To do so, we study two …
and the macroscale functional response of collagenous tissues. To do so, we study two …
Mechanical load induces a 100-fold increase in the rate of collagen proteolysis by MMP-1
AS Adhikari, J Chai, AR Dunn - Biophysical Journal, 2011 - cell.com
Both mechanotransduction and extracellular matrix (ECM) proteolytic remodeling are critical
during embryonic development and in disease progression. Although mechanical stress is …
during embryonic development and in disease progression. Although mechanical stress is …
Tendon extracellular matrix assembly, maintenance and dysregulation throughout life
Abstract In his Lissner Award medal lecture in 2000, Stephen Cowin asked the
question:“How is a tissue built?” It is not a new question, but it remains as relevant today as it …
question:“How is a tissue built?” It is not a new question, but it remains as relevant today as it …
Load transfer, damage, and failure in ligaments and tendons
The function of ligaments and tendons is to support and transmit loads applied to the
musculoskeletal system. These tissues are often able to perform their function for many …
musculoskeletal system. These tissues are often able to perform their function for many …
Evaluation of fundamental hypotheses underlying constrained mixture models of arterial growth and remodelling
A Valentin, JD Humphrey - Philosophical Transactions of …, 2009 - royalsocietypublishing.org
Evolving constituent composition and organization are important determinants of the
biomechanical behaviour of soft tissues. In arteries, vascular smooth muscle cells and …
biomechanical behaviour of soft tissues. In arteries, vascular smooth muscle cells and …
[HTML][HTML] The shift in macrophages polarisation after tendon injury: A systematic review
Background The role of macrophages (Mφs) in tendon injury healing is controversy. The
aims of this study were to determine whether there is a shift in Mφs polarisation after an …
aims of this study were to determine whether there is a shift in Mφs polarisation after an …