Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives

D Sharma, B Narasimhan, P Kumar, V Judge… - European journal of …, 2009 - Elsevier
In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1–12) and
(substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13–26) analogues …

The role of physicochemical and topological parameters in drug design

J Darlami, S Sharma - Frontiers in Drug Discovery, 2024 - frontiersin.org
Quantitative structure activity relationship (QSAR) is a widely used tool in rational drug
design that establishes relationships between the physicochemical and topological …

[HTML][HTML] Comparative biocompatibility and antimicrobial studies of sorbic acid derivates

D Nemes, R Kovács, F Nagy, Z Tóth, P Herczegh… - European Journal of …, 2020 - Elsevier
Nowadays, the sorbates are the third largest group of antimicrobial preservatives in food and
pharmaceutical industries, following the parabens and benzoates whose safety is …

Synthesis of quinoline acetohydrazide-hydrazone derivatives evaluated as DNA gyrase inhibitors and potent antimicrobial agents

P Sridhar, M Alagumuthu, S Arumugam, SR Reddy - RSC advances, 2016 - pubs.rsc.org
The (E)-N′-(substituted-benzylidene)-2-(7-fluoro-2-methoxyquinolin-8-yl) acetohydrazide-
hydrazone derivatives reported in this manuscript represent a new series of antibacterial …

Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones

D Sharma, B Narasimhan, P Kumar… - European journal of …, 2009 - Elsevier
A series of 2-(substituted phenyl)-1H-benzimidazole (1–10) and [2-(substituted phenyl)-
benzimidazol-1-yl]-pyridin-3-yl-methanone (11–19) derivatives were synthesized and tested …

Solubility and solution thermodynamics of sorbic acid in eight pure organic solvents

J Fang, M Zhang, P Zhu, J Ouyang, J Gong… - The Journal of Chemical …, 2015 - Elsevier
By the gravimetric method, the solubility of sorbic acid in eight solvents including ethanol, 2-
propanol, methanol, 1-butanol, ethyl acetate, methyl tert-butyl ether, acetone and acetonitrile …

Isonicotinic acid hydrazide derivatives: synthesis, antimicrobial activity, and QSAR studies

V Judge, B Narasimhan, M Ahuja, D Sriram… - Medicinal Chemistry …, 2012 - Springer
A series of isonicotinic acid hydrazide derivatives (1–19) was synthesized and tested in vitro
for antimycobacterial activity against Mycobacterium tuberculosis and antimicrobial activity …

[HTML][HTML] Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1, 2-dihydro-indol-3-ylideneamino)-N-substituted benzene …

M Kumar, K Ramasamy, V Mani, RK Mishra… - Arabian Journal of …, 2014 - Elsevier
Abstract A series of 4-(1-aryl-2-oxo-1, 2-dihydro-indol-3-ylideneamino)-N-substituted
benzenesulfonamide derivatives (1–32) was synthesized and evaluated for its in vitro …

Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation

D Kumar, V Judge, R Narang, S Sangwan… - European Journal of …, 2010 - Elsevier
A series of benzylidene hydrazides (1–20) was synthesized and tested, in vitro, for
antibacterial, antifungal and antiviral activities. The microbial screening results indicated that …

Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of nicotinic acid benzylidene hydrazide derivatives

R Narang, B Narasimhan, S Sharma, D Sriram… - Medicinal Chemistry …, 2012 - Springer
A series of nicotinic acid benzylidene hydrazide derivatives (1–18) was synthesized and
tested in vitro for biological evaluations. The antimycobacterial activity results indicated that …