Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view

N Chadha, O Silakari - European Journal of Medicinal Chemistry, 2017 - Elsevier
Indoles constitute extensively explored heterocyclic ring systems with wide range of
applications in pathophysiological conditions that is, cancer, microbial and viral infections …

A review on recent developments of indole-containing antiviral agents

MZ Zhang, Q Chen, GF Yang - European journal of medicinal chemistry, 2015 - Elsevier
Indole represents one of the most important privileged scaffolds in drug discovery. Indole
derivatives have the unique property of mimicking the structure of peptides and to bind …

Indole–a promising pharmacophore in recent antiviral drug discovery

A Dorababu - RSC Medicinal Chemistry, 2020 - pubs.rsc.org
The bicyclic molecule indole has been in the limelight because of its numerous
pharmacological potencies. It is used as an excellent scaffold in drug discovery of medicinal …

Phytochemical Moieties From Indian Traditional Medicine for Targeting Dual Hotspots on SARS-CoV-2 Spike Protein: An Integrative in-silico Approach

V Umashankar, SH Deshpande, HV Hegde… - Frontiers in …, 2021 - frontiersin.org
SARS-CoV-2 infection across the world has led to immense turbulence in the treatment
modality, thus demanding a swift drug discovery process. Spike protein of SARS-CoV-2 …

Antiviral active compounds derived from natural sources against herpes simplex viruses

L van de Sand, M Bormann, Y Schmitz, CS Heilingloh… - Viruses, 2021 - mdpi.com
Herpes simplex viruses (HSV) are ubiquitously distributed with a seroprevalence ranging up
to 95% in the adult population. Refractory viral infections with herpes simplex virus type 1 …

Experimental Dissection of the Lytic Replication Cycles of Herpes Simplex Viruses in vitro

FJ Ibáñez, MA Farías, MP Gonzalez-Troncoso… - Frontiers in …, 2018 - frontiersin.org
Herpes simplex viruses type 1 and type 2 (HSV-1 and HSV-2) produce lifelong infections
and are highly prevalent in the human population. Both viruses elicit numerous clinical …

Recent update on anti-dengue drug discovery

SN Dighe, K Dua, DK Chellappan, PL Katavic… - European journal of …, 2019 - Elsevier
Dengue is the most important arthropod-borne viral disease of humans, with more than half
of the global population living in at-risk areas. Despite the negative impact on public health …

Fluorescein derived Schiff base as fluorimetric zinc (II) sensor via 'turn on'response and its application in live cell imaging

B Das, A Jana, AD Mahapatra, D Chattopadhyay… - … Acta Part A: Molecular …, 2019 - Elsevier
A novel Schiff base L composed of fluorescein hydrazine and a phenol functionalized moiety
has been designed and prepared via cost-effective condensation reaction. The L is utilized …

Harmine blocks herpes simplex virus infection through downregulating cellular NF-κB and MAPK pathways induced by oxidative stress

D Chen, A Su, Y Fu, X Wang, X Lv, W Xu, S Xu… - Antiviral research, 2015 - Elsevier
Herpes simplex virus types 1 and 2 (HSV-1 and-2) are highly prevalent in many populations
and therapeutic options are limited. Both viruses can establish latency by maintaining viral …

Specialized metabolites from plants as a source of new multi-target antiviral drugs: a systematic review

M Ponticelli, ML Bellone, V Parisi, A Iannuzzi… - Phytochemistry …, 2023 - Springer
Viral infections have always been the main global health challenge, as several potentially
lethal viruses, including the hepatitis virus, herpes virus, and influenza virus, have affected …