Recent advances in microfluidic single-cell analysis and its applications in drug development

Y Jiao, L Gao, Y Ji, W Liu - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Cellular heterogeneity is prevalent in all cell populations. Single-cell analysis (SCA) could
unveil the heterogeneity and thus gain unique insights into complex biological processes …

Functional precision cancer medicine: drug sensitivity screening enabled by cell culture models

Å Flobak, SS Skånland, E Hovig, K Taskén… - Trends in …, 2022 - cell.com
Functional precision medicine is a new, emerging area that can guide cancer treatment by
capturing information from direct perturbations of tumor-derived, living cells, such as by drug …

Characterization of AI-enhanced magnetophoretic transistors operating in a tri-axial magnetic field for on-chip bioparticle sorting

R Abedini-Nassab, E Adibi, S Ahmadiasl - Scientific Reports, 2024 - nature.com
We demonstrate two general classes of magnetophoretic transistors, called the “trap” and
the “repel-and-collect” transistors, capable of switching single magnetically labeled cells and …

Microfluidic Impedance Cytometry Enabled One‐Step Sample Preparation for Efficient Single‐Cell Mass Spectrometry

J Zhu, S Pan, H Chai, P Zhao, Y Feng, Z Cheng… - Small, 2024 - Wiley Online Library
Single‐cell mass spectrometry (MS) is significant in biochemical analysis and holds great
potential in biomedical applications. Efficient sample preparation like sorting (ie, separating …

Convenient tumor 3D spheroid arrays manufacturing via acoustic excited bubbles for in situ drug screening

J Zheng, X Hu, X Gao, Y Liu, S Zhao, L Chen, G He… - Lab on a Chip, 2023 - pubs.rsc.org
The quick and convenient fabrication of in vitro tumor spheroids models has been pursued
for clinical drug discovery and personalized therapy. Here, uniform three-dimensional (3D) …

Performance-enhanced clogging-free viscous sheath constriction impedance flow cytometry

J Zhu, Y Feng, H Chai, F Liang, Z Cheng, W Wang - Lab on a Chip, 2023 - pubs.rsc.org
As a label-free and high-throughput single cell analysis platform, impedance flow cytometry
(IFC) suffers from clogging caused by a narrow microchannel as mechanical constriction …

Transcribing the enigma: the B chromosome as a territory of uncharted RNAs

JIN Oliveira, DC Cabral-de-Mello, GT Valente… - Genetics, 2024 - academic.oup.com
B chromosomes are supernumerary elements found in several groups of eukaryotes,
including fungi, plants, and animals. Typically, these chromosomes either originate from …

One-step fabrication of droplet arrays using a biomimetic structural chip

L Du, Y Li, X Zhang, Z Zhou, Y Wang… - ACS Applied Materials …, 2023 - ACS Publications
In the field of one-step efficient preparation of dewetting droplet arrays, the process is
hampered by the requirement for low chemical wettability of solid surfaces, which restricts …

Recent advances in microfluidics for single-cell functional proteomics

ST Gebreyesus, G Muneer, CC Huang, AA Siyal… - Lab on a Chip, 2023 - pubs.rsc.org
Single-cell proteomics (SCP) reveals phenotypic heterogeneity by profiling individual cells,
their biological states and functional outcomes upon signaling activation that can hardly be …

Enhancing microdroplet array generation via heterogeneous inner surface Modification: Biomimetic & hydrophobic approach

L Du, Z Zhou, J Wang, D Zhang, Y Li, J Zhou… - Chemical Engineering …, 2024 - Elsevier
Microdroplet array chips have great potential for biological applications. Both physical
structure and chemical material modification are effective surface modification techniques for …