The field of tissue engineering has advanced over the past decade, but the largest impact on
human health should be achieved with the transition of engineered solid organs to the clinic …

Blood-contacting surfaces of cardiovascular devices are not biocompatible for creating an
endothelial layer on them. Numerous research studies have mainly sought to modify these …

Decellularization of tissues and organs has recently become a promising approach in tissue
engineering and regenerative medicine to circumvent the challenges of organ donation and …

Electrospun polycaprolactone (PCL) tissue engineering scaffolds have been developed and
used for a wide range of tissue engineering applications, where successful incorporation …

One of the major challenges in the field of regenerative medicine is how to optimize tissue
regeneration in the body by therapeutically manipulating its natural ability to form scar at the …

Despite the efforts devoted to drug discovery and development, the number of new drug
approvals have been decreasing. Specifically, cardiovascular developments have been …

Surgical replacement of diseased heart valves by mechanical and tissue valve substitutes is
now commonplace and generally enhances survival and quality of life. However, a …

Whole‐organ decellularization has been identified as a promising choice for tissue
engineering. The aim of the present study was to engineer intact whole rat liver scaffolds …

OBJECTIVE: Mechanical and biological prostheses are used to replace damaged heart
valves but are associated with significant morbidities. Although there is increased interest in …

Ectopic calcification of native and bioprosthetic heart valves represents a major public health
problem causing severe morbidity and mortality worldwide. Valve procalcific degeneration is …