Cilia and flagella are microtubule‐based antenna which are highly conserved among
eukaryotes. In vertebrates, primary and motile cilia have evolved to exert several key …

In the last twenty years, research using zebrafish as a model organism has increased
immensely. With the many advantages that zebrafish offer such as high fecundity, optical …

The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is frequently
reported to be hyperactivated in hepatocellular carcinoma (HCC) and contributes to HCC …

Kinesins are motor proteins involved in microtubule (MT)-mediated intracellular transport.
They contribute to key cellular processes, including intracellular trafficking, organelle …

Autophagy is a catabolic process responsible for the removal of waste and damaged cellular
components by lysosomal degradation. It plays a key role in fundamental cell processes …

The CRISPR/Cas9 system has emerged as a powerful tool for mammalian genome
engineering. In basic and translational intervertebral disc (IVD) research, this technique has …

Human CLCN7 encodes voltage-gated chloride channel 7 (ClC-7); mutations of CLCN7
lead to osteopetrosis which is characterized by increased bone mass and impaired …

Kyphomelic dysplasia is a heterogeneous group of skeletal dysplasias characterized by
severe bowing of the limbs associated with other variable findings, such as narrow thorax …

Background Kinesin motor proteins transport intracellular cargo, including mRNA, proteins,
and organelles. Pathogenic variants in kinesin-related genes have been implicated in …

Oligodendrocytes are the myelinating cells in the central nervous system. In birds and
mammals, the oligodendrocyte progenitor cells (OPCs) originate in the preoptic area (POA) …