Advances in the field of boron chemistry have expanded the application of boron from
material use to medicine. Boron-based drugs represent a new class of molecules that …

Breast cancer is a heterogeneous disease, encompassing a large number of entities
showing different morphological features and having clinical behaviors. It has became …

Background: Drug response prediction is an important problem in computational
personalized medicine. Many machine-learning-based methods, especially deep learning …

The ubiquitin-proteasome pathway degrades ubiquitinated proteins to remove damaged or
misfolded protein and thus plays an important role in the maintenance of many important …

The ubiquitin-proteasome system plays a key regulatory role in cellular homeostasis. The
inhibition of the 26S proteasome by Bortezomib leads to the accumulation of misfolded …

Bortezomib represents the first proteasome inhibitor (PI) with demonstrated antitumor activity
in the clinical setting, particularly for treatment of hematological malignancies. At the …

The antitumor activity of an inhibitor of 26S proteasome bortezomib (Velcade) has been
observed in various malignancies, including colon cancer, prostate cancer, breast cancer …

Abstract Background Cytoplasmic stress granules (SGs) are specialized storage sites of
untranslated mRNAs whose formation occurs under different stress conditions and is often …

Introduction Triple negative breast cancer (TNBC) is very aggressive and currently has no
specific therapeutic targets, such as hormone receptors or human epidermal growth factor …

Abstract Development of effective cancer therapeutic strategies relies on our ability to
interfere with cellular processes that are dysregulated in tumors. Given the essential role of …