Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Neurons affected in Alzheimer's disease (AD) experience mitochondrial dysfunction and a
bioenergetic deficit that occurs early and promotes the disease-defining amyloid beta …

Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

A variety of cognitive disorders are worsened by stress exposure and involve dysfunction of
the newly evolved prefrontal cortex (PFC). Exposure to acute, uncontrollable stress …

Redox equilibria and the modulation of redox signalling play crucial roles in physiological
processes. Overproduction of reactive oxygen species (ROS) disrupts the body's antioxidant …

Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases,
including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and …

Aging is the main risk factor for neurodegenerative diseases. In aging, microglia undergoes
phenotypic changes compatible with their activation. Glial activation can lead to …

Oxidative stress plays a significant role in the pathogenesis of Alzheimer's disease (AD), a
devastating disease of the elderly. The brain is more vulnerable than other organs to …

Mitochondria not only supply the energy for cell function, but also take part in cell signaling.
This review describes the dysfunctions of mitochondria in aging and neurodegenerative …

Alzheimer′ s disease (AD) is the most common neurodegenerative disease that causes
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …