Stroke represents a massive public health problem. Carotid atherosclerosis plays a
fundamental part in the occurence of ischaemic stroke. European and US guidelines for …

Immunotherapy, specifically the introduction of immune checkpoint inhibitors, has
transformed the treatment of cancer, enabling long-term tumour control even in individuals …

Background: Elevated lipoprotein (a)[Lp (a)] is a prevalent, independent cardiovascular risk
factor, but the underlying mechanisms responsible for its pathogenicity are poorly defined …

Background—The diagnosis of infective endocarditis (IE) in prosthetic valves and
intracardiac devices is challenging because both the modified Duke criteria (DC) and …

Carotid artery stenosis is a well-established risk factor of ischemic stroke, contributing to up
to 10%-20% of strokes or transient ischemic attacks. Many clinical trials over the last 20 …

Objectives: The study sought to test whether high-dose statin treatment would result in
greater reductions in plaque inflammation than low-dose statins, using fluorodeoxyglucose …

PET imaging of atherosclerosis can quantify several in vivo pathological processes
occurring within the arterial system. 18F-fluorodeoxyglucose (FDG) is the most-commonly …

Context Cardiovascular disease is increased in patients with human immunodeficiency virus
(HIV), but the specific mechanisms are unknown. Objective To assess arterial wall …

Objectives: This study sought to determine whether arterial inflammation measured by 18F-
fluorodeoxyglucose positron emission tomography (18F-FDG-PET) improves prediction of …

Background Dalcetrapib modulates cholesteryl ester transfer protein (CETP) activity to raise
high-density lipoprotein cholesterol (HDL-C). After the failure of torcetrapib it was unknown if …