Although integrins are known to be mechanosensitive and to possess many subtypes that
have distinct physiological roles, single molecule studies of force exertion have thus far …

Without differentiated inner and outer biological function, expanded polytetrafluoroethylene
(ePTFE) small-diameter (< 6 mm) artificial blood vessels would fail in vivo due to foreign …

Cells constantly experience mechanical forces during growth and development. Increasing
evidence suggests that mechanical forces can regulate cellular processes such as …

Cell–matrix adhesions play an essential role in mediating and regulating many biological
processes. The adhesion receptors, typically transmembrane integrins, provide dynamic …

Cancer metastasis is affected by chemical factors and physical cues. From cell adhesion to
migration, mechanical tension applied to integrin expresses on the cell membrane and …

Background The proliferation of airway smooth muscle cells (ASMCs) contributes to the
contractility and inflammation in the pathophysiology of asthma. This intrigued us to clarify …

Physical interactions between cells and micro/nanometer-sized architecture presented in an
extracellular matrix (ECM) environment significantly influence cell adhesion and …

Childhood asthma is one of the most common respiratory diseases with rising mortality and
morbidity. The multi-omics data is providing a new chance to explore collaborative …

Asthma is a serious global health problem affecting 300 million persons around the world.
Mast cells (MCs) play a major role in airway hyperresponsiveness (AHR) and inflammation …

Recent developments of single-molecule and super-resolution microscopies reveal novel
spatial-temporal features of various cellular processes with unprecedented details, and …