Abstract Development of resistance to chemotherapy in cancer continues to be a major
challenge in cancer management. Ferroptosis, a unique type of cell death, is mechanistically …

Ferroptosis is a recently defined form of regulated cell death, which is biochemically and
morphologically distinct from traditional forms of programmed cell death such as apoptosis …

Background Pancreatic cancer continues to be one of the world's most lethal cancers.
Chemotherapy resistance in patients with advanced pancreatic cancer often accompany …

Simple Summary The dysregulation of ACSL3 and ACSL4, which belong to the long-chain
fatty acyl CoA synthetase family (ACSLs), affects the behavior of various cancer cells. This …

Background Steatotic livers tolerate ischemia–reperfusion injury (IRI) poorly, increasing the
risk of organ dysfunction. Ferroptosis is considered the initiating factor of organ IRI. Heme …

Hepatocellular carcinoma is the most prevalent form of primary liver cancer with a
multifactorial aetiology comprising genetic, environmental, and behavioural factors. Evading …

Oxaliplatin is a widely used chemotherapy drug for patients with advanced colorectal cancer
(CRC); however, frequent drug resistance limits its therapeutic efficacy in patients. Here, this …

Ferroptosis is an iron-dependent form of cell death, which is triggered by disturbed
membrane integrity due to an overproduction of lipid peroxides. Induction of ferroptosis …

Ischemia/reperfusion injury (IRI) is prone to occur after kidney transplantation, leading to
delayed graft function (DGF). MicroRNAs play a crucial role in the pathogenesis of …

A potential reason for the failure of tumor therapies is treatment resistance. Resistance to
chemotherapy, radiotherapy, and immunotherapy continues to be a major obstacle in clinic …