Application of nano-based systems for drug delivery and targeting: a review
Over the last decades, magnificent progress in the field of nanopharmaceuticals mostly with
sizes smaller than 100 nm has led to the development of novel delivery systems and …
sizes smaller than 100 nm has led to the development of novel delivery systems and …
Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles
Cytoplasmic delivery of bioactives requires the use of strategies such as active transport,
electroporation, or the use of nanocarriers such as polymeric nanoparticles, liposomes …
electroporation, or the use of nanocarriers such as polymeric nanoparticles, liposomes …
Spermine-Based Poly (β-amino ester) s for siRNA Delivery against Mutated KRAS in Lung Cancer
Y Jin, F Adams, L Isert, D Baldassi… - Molecular …, 2023 - ACS Publications
Polyethylenimine (PEI) is a highly efficient cationic polymer for nucleic acid delivery, and
although it is commonly used in preclinical studies, its clinical application is limited because …
although it is commonly used in preclinical studies, its clinical application is limited because …
Copper-Catalyzed Synthesis of Quinoline-4-thiols from Diaryliodonium Salts, Alkynyl Sulfides, and Nitriles
S Chang, D Xing, Y Zheng, L Huang - Organic Letters, 2023 - ACS Publications
A three-component cascade cyclization catalyzed by copper was employed to synthesize
quinoline-4-thiols using easily available diaryliodonium salts, alkynyl sulfides, and nitriles as …
quinoline-4-thiols using easily available diaryliodonium salts, alkynyl sulfides, and nitriles as …
Incorporation of endosomolytic peptides with varying disruption mechanisms into EGFR-Targeted protein conjugates: the effect on intracellular protein delivery and …
Intracellular delivery of protein therapeutics remains a significant challenge limiting the
majority of clinically available protein drugs to extracellular targets. Strategies to deliver …
majority of clinically available protein drugs to extracellular targets. Strategies to deliver …
Application of chloroquine as an endosomal escape enhancing agent: new frontiers for an old drug
M Hajimolaali, H Mohammadian, A Torabi… - Expert opinion on …, 2021 - Taylor & Francis
Introduction Adequate transfection efficiency is indispensable to safe and effective delivery
of therapeutically active agents, particularly in cancer. Endosomal escape is regarded as a …
of therapeutically active agents, particularly in cancer. Endosomal escape is regarded as a …
Identification of a Dual Autophagy and REV-ERB Inhibitor with in Vivo Anticancer Efficacy
M Palomba, D Vecchio, G Allavena… - Journal of Medicinal …, 2023 - ACS Publications
The autophagy process appears as a promising target for anticancer interventions.
Chloroquine (CQ) and its derivative hydroxychloroquine (HCQ) are the only FDA-approved …
Chloroquine (CQ) and its derivative hydroxychloroquine (HCQ) are the only FDA-approved …
USP1-Associated Factor 1 Modulates Japanese Encephalitis Virus Replication by Governing Autophagy and Interferon-Stimulated Genes
J Xing, C Hu, S Che, Y Lan, L Huang, L Liu… - Microbiology …, 2023 - Am Soc Microbiol
Japanese encephalitis virus (JEV) is a typical mosquito-borne flavivirus that can cause
central nervous system diseases in humans and animals. Host factors attempt to limit virus …
central nervous system diseases in humans and animals. Host factors attempt to limit virus …
[HTML][HTML] Correlation between biophysical properties of niosomes elaborated with chloroquine and different tensioactives and their transfection efficiency
M Sainz-Ramos, I Villate-Beitia, I Gallego, N Al Qtaish… - Pharmaceutics, 2021 - mdpi.com
Lipid nanocarriers, such as niosomes, are considered attractive candidates for non-viral
gene delivery due to their suitable biocompatibility and high versatility. In this work, we …
gene delivery due to their suitable biocompatibility and high versatility. In this work, we …
Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron: Design, synthesis and biological evaluation of dual-functional …
HT Zhi, Z Lu, L Chen, JQ Wu, L Li, J Hu, WH Chen - Bioorganic Chemistry, 2024 - Elsevier
Targeting the homeostasis of anions and iron has emerged as a promising therapeutic
approach for the treatment of cancers. However, single-targeted agents often fall short of …
approach for the treatment of cancers. However, single-targeted agents often fall short of …