Over the last decades, magnificent progress in the field of nanopharmaceuticals mostly with
sizes smaller than 100 nm has led to the development of novel delivery systems and …

Cytoplasmic delivery of bioactives requires the use of strategies such as active transport,
electroporation, or the use of nanocarriers such as polymeric nanoparticles, liposomes …

Polyethylenimine (PEI) is a highly efficient cationic polymer for nucleic acid delivery, and
although it is commonly used in preclinical studies, its clinical application is limited because …

A three-component cascade cyclization catalyzed by copper was employed to synthesize
quinoline-4-thiols using easily available diaryliodonium salts, alkynyl sulfides, and nitriles as …

Intracellular delivery of protein therapeutics remains a significant challenge limiting the
majority of clinically available protein drugs to extracellular targets. Strategies to deliver …

Introduction Adequate transfection efficiency is indispensable to safe and effective delivery
of therapeutically active agents, particularly in cancer. Endosomal escape is regarded as a …

The autophagy process appears as a promising target for anticancer interventions.
Chloroquine (CQ) and its derivative hydroxychloroquine (HCQ) are the only FDA-approved …

Japanese encephalitis virus (JEV) is a typical mosquito-borne flavivirus that can cause
central nervous system diseases in humans and animals. Host factors attempt to limit virus …

Lipid nanocarriers, such as niosomes, are considered attractive candidates for non-viral
gene delivery due to their suitable biocompatibility and high versatility. In this work, we …

Targeting the homeostasis of anions and iron has emerged as a promising therapeutic
approach for the treatment of cancers. However, single-targeted agents often fall short of …