Neurobiology of depression in Parkinson's disease: Insights into epidemiology, molecular mechanisms and treatment strategies

MH Ahmad, MA Rizvi, M Ali, AC Mondal - Ageing research reviews, 2023 - Elsevier
Parkinson's disease (PD) is characterized mainly by motor dysfunctions due to the
progressive loss of dopaminergic neurons. However, PD patients experience a multitude of …

[HTML][HTML] Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease …

P Odin, KR Chaudhuri, JT Slevin, J Volkmann… - Parkinsonism & Related …, 2015 - Elsevier
Navigate PD was an educational program established to supplement existing guidelines
and provide recommendations on the management of Parkinson's disease (PD) refractory to …

Selecting deep brain stimulation or infusion therapies in advanced Parkinson's disease: an evidence-based review

J Volkmann, A Albanese, A Antonini, KR Chaudhuri… - Journal of …, 2013 - Springer
Motor complications in Parkinson's disease (PD) result from the short half-life and irregular
plasma fluctuations of oral levodopa. When strategies of providing more continuous …

Apomorphine-pharmacological properties and clinical trials in Parkinson's disease

P Jenner, R Katzenschlager - Parkinsonism & related disorders, 2016 - Elsevier
Apomorphine is often considered an archetypal dopamine agonist used in the treatment of
Parkinson's disease (PD). However, it can be clearly differentiated from most other …

Quality of life in Parkinson's disease improved by apomorphine pump: the OPTIPUMP cohort study

S Drapier, A Eusebio, B Degos, M Vérin, F Durif… - Journal of …, 2016 - Springer
To report on OPTIPUMP, a cohort study, investigating the impact in real-life clinical settings
of continuous subcutaneous apomorphine infusion (CSAI) on the quality of life (HRQoL) of …

Clinical and neuropsychological follow up at 12 months in patients with complicated Parkinson's disease treated with subcutaneous apomorphine infusion or deep …

D De Gaspari, C Siri, A Landi, R Cilia… - Journal of Neurology …, 2006 - jnnp.bmj.com
Background: The clinical condition of advanced Parkinson's disease (PD) patients is often
complicated by motor fluctuations and dyskinesias which are difficult to control with available …

The role of dopamine agonists in the treatment of depression in patients with Parkinson's disease: a systematic review

AFG Leentjens - Drugs, 2011 - Springer
Depressive disorders as well as depressive symptoms are common in Parkinson's disease
(PD) and an important factor affecting quality of life. Treatment of depressive symptoms not …

Translating evidence to advanced Parkinson's disease patients: a systematic review and meta‐analysis

FAP Nijhuis, R Esselink, RMA de Bie… - Movement …, 2021 - Wiley Online Library
In the advanced stages of Parkinson's disease (PD), patients frequently experience
disabling motor complications. Treatment options include deep brain stimulation (DBS) …

Pharmacological insights into the use of apomorphine in Parkinson's disease: clinical relevance

M Auffret, S Drapier, M Vérin - Clinical drug investigation, 2018 - Springer
The present paper consists of a comprehensive review of the literature on apomorphine
pharmacological properties and its usefulness in Parkinson's disease (PD). The chemistry …

New drug delivery strategies for improved Parkinson's disease therapy

A Di Stefano, P Sozio, A Iannitelli… - Expert opinion on drug …, 2009 - Taylor & Francis
Increasing interest has been addressed toward the introduction of new therapeutic
approaches to obtaining continuous dopaminergic stimulation (CDS). The goal of this …