The pathology and pathophysiology of vascular dementia

RN Kalaria - Neuropharmacology, 2018 - Elsevier
Vascular dementia (VaD) is widely recognised as the second most common type of
dementia. Consensus and accurate diagnosis of clinically suspected VaD relies on wide …

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease

RN Kalaria - Acta neuropathologica, 2016 - Springer
Vascular dementia (VaD) is recognised as a neurocognitive disorder, which is explained by
numerous vascular causes in the general absence of other pathologies. The heterogeneity …

Brain arteriolosclerosis

BL Blevins, HV Vinters, S Love, DM Wilcock… - Acta …, 2021 - Springer
Abstract Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …

Association of cerebral microbleeds with cognitive decline and dementia

S Akoudad, FJ Wolters, A Viswanathan… - JAMA …, 2016 - jamanetwork.com
Importance Cerebral microbleeds are hypothesized downstream markers of brain damage
caused by vascular and amyloid pathologic mechanisms. To date, whether their presence is …

Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

D Wilson, G Ambler, KJ Lee, JS Lim… - The Lancet …, 2019 - thelancet.com
Background Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial
clinical question is whether cerebral microbleeds indicate patients with recent ischaemic …

White matter degeneration in vascular and other ageing‐related dementias

Y Hase, K Horsburgh, M Ihara… - Journal of …, 2018 - Wiley Online Library
Advances in neuroimaging have enabled greater understanding of the progression of
cerebral degenerative processes associated with ageing‐related dementias. Leukoaraiosis …

Cerebral microbleeds are associated with an increased risk of stroke: the Rotterdam Study

S Akoudad, MLP Portegies, PJ Koudstaal, A Hofman… - Circulation, 2015 - Am Heart Assoc
Background—Cerebral microbleeds are highly prevalent in people with clinically manifest
cerebrovascular disease and have been shown to increase the risk of stroke recurrence …

Cerebral microbleeds: from depiction to interpretation

L Puy, M Pasi, M Rodrigues, SJ Van Veluw… - Journal of Neurology …, 2021 - jnnp.bmj.com
Cerebral microbleeds (CMBs) are defined as hypointense foci visible on T2*-weighted and
susceptible-weighted MRI sequences. CMBs are increasingly recognised with the …

Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA: a meta-analysis

D Wilson, A Charidimou, G Ambler, ZV Fox… - Neurology, 2016 - AAN Enterprises
Objective: To determine associations between cerebral microbleed (CMB) burden with
recurrent ischemic stroke (IS) and intracerebral hemorrhage (ICH) risk after IS or TIA …

Post-mortem assessment in vascular dementia: advances and aspirations

KE McAleese, I Alafuzoff, A Charidimou, J De Reuck… - BMC medicine, 2016 - Springer
Background Cerebrovascular lesions are a frequent finding in the elderly population.
However, the impact of these lesions on cognitive performance, the prevalence of vascular …