Regulation and role of fungal secondary metabolites

J Macheleidt, DJ Mattern, J Fischer… - Annual review of …, 2016 - annualreviews.org
Fungi have the capability to produce a tremendous number of so-called secondary
metabolites, which possess a multitude of functions, eg, communication signals during …

Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era

HU Van Der Heul, BL Bilyk, KJ McDowall… - Natural product …, 2018 - pubs.rsc.org
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

[HTML][HTML] Recent advances in understanding Streptomyces

KF Chater - F1000Research, 2016 - ncbi.nlm.nih.gov
Abstract About 2,500 papers dated 2014–2016 were recovered by searching the PubMed
database for Streptomyces, which are the richest known source of antibiotics. This review …

Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp.

G Niu, KF Chater, Y Tian, J Zhang… - FEMS Microbiology …, 2016 - academic.oup.com
Streptomyces bacteria are the major source of antibiotics and other secondary metabolites.
Various environmental and physiological conditions affect the onset and level of production …

Competition Sensing Changes Antibiotic Production in Streptomyces

S Westhoff, AM Kloosterman, SFA van Hoesel… - MBio, 2021 - Am Soc Microbiol
One of the most important ways that bacteria compete for resources and space is by
producing antibiotics that inhibit competitors. Because antibiotic production is costly, the …

Use of elicitors to enhance or activate the antibiotic production in streptomyces

G Zong, J Fu, P Zhang, W Zhang, Y Xu… - Critical Reviews in …, 2022 - Taylor & Francis
Streptomyces is the largest and most significant genus of Actinobacteria, comprising 961
species. These Gram-positive bacteria produce many versatile and important bioactive …

Regulation of Antibiotic Production by Signaling Molecules in Streptomyces

D Kong, X Wang, J Nie, G Niu - Frontiers in Microbiology, 2019 - frontiersin.org
The genus Streptomyces is a unique subgroup of actinomycetes bacteria that are well-
known as prolific producers of antibiotics and many other bioactive secondary metabolites …

Efflux transporter ArsK is responsible for bacterial resistance to arsenite, antimonite, trivalent roxarsone, and methylarsenite

K Shi, C Li, C Rensing, X Dai, X Fan… - Applied and …, 2018 - Am Soc Microbiol
Arsenic-resistant bacteria have evolved various efflux systems for arsenic resistance. Five
arsenic efflux proteins, ArsB, Acr3, ArsP, ArsJ, and MSF1, have been reported. In this study …

Activation and mechanism of a cryptic oviedomycin gene cluster via the disruption of a global regulatory gene, adpA, in Streptomyces ansochromogenes

J Xu, J Zhang, J Zhuo, Y Li, Y Tian, H Tan - Journal of Biological Chemistry, 2017 - ASBMB
Genome sequencing analysis has revealed at least 35 clusters of likely biosynthetic genes
for secondary metabolites in Streptomyces ansochromogenes. Disruption of adpA encoding …

[HTML][HTML] Coordinated regulation for nature products discovery and overproduction in Streptomyces

Q Zhou, S Ning, Y Luo - Synthetic and Systems Biotechnology, 2020 - Elsevier
Streptomyces is an important treasure trove for natural products discovery. In recent years,
many scientists focused on the genetic modification and metabolic regulation of …