Measuring the tail: Methods for poly (A) tail profiling

A Brouze, PS Krawczyk… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Abstract The 3′‐end poly (A) tail is an important and potent feature of most mRNA
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …

PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3′ end sequencing

CJ Herrmann, R Schmidt, A Kanitz, P Artimo… - Nucleic acids …, 2020 - academic.oup.com
Generated by 3′ end cleavage and polyadenylation at alternative polyadenylation (poly
(A)) sites, alternative terminal exons account for much of the variation between human …

Mechanisms of lineage specification in Caenorhabditis elegans

J Liu, JI Murray - Genetics, 2023 - academic.oup.com
The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …

Specialized germline P-bodies are required to specify germ cell fate in Caenorhabditis elegans embryos

M Cassani, G Seydoux - Development, 2022 - journals.biologists.com
In animals with germ plasm, specification of the germline involves 'germ granules',
cytoplasmic condensates that enrich maternal transcripts in the germline founder cells. In …

mRNA localization is linked to translation regulation in the Caenorhabditis elegans germ lineage

DM Parker, LP Winkenbach, S Boyson… - …, 2020 - journals.biologists.com
Caenorhabditis elegans early embryos generate cell-specific transcriptomes despite lacking
active transcription, thereby presenting an opportunity to study mechanisms of post …

The role of RNA-binding proteins in orchestrating germline development in Caenorhabditis elegans

MMY Albarqi, SP Ryder - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
RNA passed from parents to progeny controls several aspects of early development. The
germline of the free-living nematode Caenorhabditis elegans contains many families of …

Germline immortality relies on TRIM32-mediated turnover of a maternal mRNA activator in C. elegans

TD Oyewale, CR Eckmann - Science Advances, 2022 - science.org
How the germ line achieves a clean transition from maternal to zygotic gene expression
control is a fundamental problem in sexually reproducing organisms. Whereas several …

CYP Gene Expression and In Vivo Biological Effects of Khat Ethanol Extract, Cathinone and Cathine in Caenorhabditis elegans

SYM Lim, MA Alshawsh… - … In Microbes & …, 2023 - journals.hh-publisher.com
The significant influence of khat, cathinone, and cathine on appetite suppression,
reproduction impairment, and inhibitory effects on CYPs enzyme activity is widely …

The endogenous mex-3 3´UTR is required for germline repression and contributes to optimal fecundity in C. elegans

MMY Albarqi, SP Ryder - PLoS Genetics, 2021 - journals.plos.org
RNA regulation is essential to successful reproduction. Messenger RNAs delivered from
parent to progeny govern early embryonic development. RNA-binding proteins (RBPs) are …

C22 disrupts embryogenesis and extends C. elegans lifespan

S Beydoun, A Sridhar, AM Tuckowski, E Wang… - Frontiers in …, 2023 - frontiersin.org
Caenorhabditis elegans is an instrumental model in aging research due to its large brood
size, short lifespan, and malleable genetics. However, maintaining a synchronous nematode …