[HTML][HTML] Chemopreventive and anticancer activity of flavonoids and its possibility for clinical use by combining with conventional chemotherapeutic agents

H Kikuchi, B Yuan, X Hu, M Okazaki - American journal of cancer …, 2019 - ncbi.nlm.nih.gov
Cancer is a diverse class of diseases characterized by uncontrolled cell growth with the
potential to invade and spread to other parts of the body, and continues to be one of the …

[HTML][HTML] Chemopreventive mechanisms of galangin against hepatocellular carcinoma: A review

D Fang, Z Xiong, J Xu, J Yin, R Luo - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common cancers and has a high
mortality rate in less developed countries, especially in China. Galangin (GA), one of the …

[HTML][HTML] Fisetin as a senotherapeutic agent: evidence and perspectives for age-related diseases

J Tavenier, JO Nehlin, MB Houlind… - Mechanisms of Ageing …, 2024 - Elsevier
Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained
attention for its potential role as a senotherapeutic agent for the treatment of age-related …

[HTML][HTML] Exploring the potential of Inula viscosa extracts for antioxidant, antiproliferative and apoptotic effects on human liver cancer cells and a molecular docking …

N Kheyar-Kraouche, S Boucheffa, Y Bellik… - …, 2023 - ncbi.nlm.nih.gov
In folk medicine, Inula viscosa (Asteraceae) has been traditionally utilized for treating
various ailments, including diabetes, bronchitis, diarrhea, rheumatism, and injuries. In this …

Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) induced cytotoxicity in HepG2 …

L Zhao, N Zhou, H Zhang, F Pan, X Ai, Y Wang… - Food and Chemical …, 2021 - Elsevier
The present study investigated the protective effects and mechanism of action of cyanidin-3-
O-glucoside (C3G) and its major metabolite protocatechuic acid (PCA) against 2-amino-1 …

Pyrazinamide drug resistance in RpsA mutant (∆438A) of Mycobacterium tuberculosis: Dynamics of essential motions and free‐energy landscape analysis

A Singh, P Somvanshi, A Grover - Journal of cellular …, 2019 - Wiley Online Library
Pyrazinamide is an essential first‐line antitubercular drug which plays pivotal role in
tuberculosis treatment. It is a prodrug that requires amide hydrolysis by mycobacterial …

Exploring the potential of bioactive compounds in preventing cancer growth and progression: A comprehensive review

M Foroughi-Gilvaee, D Martirosyan… - Bioactive Compounds in …, 2024 - ffhdj.com
Cancer stands as a prominent global cause of mortality, with a noteworthy surge in related
deaths in recent years. Over the past decade, several bioactive compounds have emerged …

Thymoquinone upregulates TRAIL/TRAILR2 expression and attenuates hepatocellular carcinoma in vivo model

SA Helmy, M El-Mesery, A El-Karef, LA Eissa… - Life sciences, 2019 - Elsevier
Aims Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related
mortality worldwide. Indeed, chemotherapeutic drugs-induced systemic toxicity results in …

Structure-based virtual screening, molecular docking, molecular dynamics simulation and pharmacokinetic modelling of cyclooxygenase-2 (COX-2) inhibitor for the …

M Yadav, M Abdalla, M Madhavi, I Chopra… - Molecular …, 2022 - Taylor & Francis
Colorectal cancer is the third most frequent cause of cancer worldwide and is more
prevalent in older individuals of all ages. The recent statistics from World Health …

Flavones as a privileged scaffold in drug discovery: Current developments

PK Boniface, FI Elizabeth - Current Organic Synthesis, 2019 - ingentaconnect.com
Background: Flavones are one of the main subclasses of flavonoids with diverse
pharmacological properties. They have been reported to possess antimalarial, antimicrobial …