A major goal in structural biology is to unravel how molecular machines function in detail. To
that end, solution-state NMR spectroscopy is ideally suited as it is able to study biological …

Unabated mining and utilisation of petroleum and petroleum resources and their conversion
to essential fuels and chemicals have drastic environmental consequences, contributing to …

INTRODUCTION Protein kinases mediate many cell signaling processes. Central to their
physiological function is the regulation of their binding and enzymatic activities, which is …

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that regulates
important functions in the central nervous system,. The ALK gene is a hotspot for …

Recently developed bioinformatic tools have bolstered the discovery of ribosomally
synthesized and post-translationally modified peptides (RiPPs). Using an improved version …

The flagellum and the injectisome enable bacterial locomotion and pathogenesis,
respectively. These nanomachines assemble and function using a type III secretion system …

Recent breakthroughs in isotope-labeling and pulse sequence techniques have enabled the
NMR characterization of large protein systems with molecular masses of hundreds of …

Molecular recognition by proteins is fundamental to the molecular basis of biology.
Dissection of the thermodynamic landscape governing protein–ligand interactions has …

Nuclear magnetic resonance (NMR) spectroscopy has been instrumental during the past
two decades in providing high-resolution structures of protein complexes. It has been the …

As structural biology trends towards larger and more complex biomolecular targets, a
detailed understanding of their interactions and underlying structures and dynamics is …