Nanotechnology-empowered lung cancer therapy: from EMT role in cancer metastasis to application of nanoengineered structures for modulating growth and …

HM Saleem, P Ramaiah, J Gupta, AT Jalil… - Environmental …, 2023 - Elsevier
Lung cancer is one of the leading causes of death in both males and females, and it is the
first causes of cancer-related deaths. Chemotherapy, surgery and radiotherapy are …

Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy

S Li, A Wang, Y Wu, S He, W Shuai… - Immunological …, 2024 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC), which has a high rate of metastatic spread and drug
resistance, is the most common subtype of lung cancer. Therefore, NSCLC patients have a …

Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction

L Jiaqi, H Siqing - Phytomedicine, 2023 - Elsevier
Background Ferroptosis, a form of regulated cell death by lipid peroxidation, was currently
considered as a key factor affecting the occurrence and progression in various cancers …

Regulation of autophagy fires up the cold tumor microenvironment to improve cancer immunotherapy

Z Jin, X Sun, Y Wang, C Zhou, H Yang… - Frontiers in …, 2022 - frontiersin.org
Immunotherapies, such as immune checkpoint inhibitors (ICIs) and chimeric antigen
receptor (CAR) T cells, have revolutionized the treatment of patients with advanced and …

Autophagy as a target for non-immune intrinsic functions of programmed cell death-ligand 1 in cancer

BE García-Pérez, C Pérez-Torres… - International Journal of …, 2023 - mdpi.com
Autophagy is a catabolic process that is essential to the maintenance of homeostasis
through the cellular recycling of damaged organelles or misfolded proteins, which sustains …

Hyaluronic acid-empowered nanotheranostics in breast and lung cancers therapy

F Alsaikhan - Environmental Research, 2023 - Elsevier
Nanomedicine application in cancer therapy is an urgency because of inability of current
biological therapies for complete removal of tumor cells. The development of smart and …

[HTML][HTML] Tetrandrine activates STING/TBK1/IRF3 pathway to potentiate anti-PD-1 immunotherapy efficacy in non-small cell lung cancer

Y Tan, Q Zhu, M Yang, F Yang, Q Zeng, Z Jiang… - Pharmacological …, 2024 - Elsevier
The efficacy of PD-1 therapy in non-small cell lung cancer (NSCLC) patients remains
unsatisfactory. Activating the STING pathway is a promising strategy to improve PD-1 …

[HTML][HTML] The therapeutic potential of andrographolide in cancer treatment

J Hu, Y Li, X Xie, Y Song, W Yan, Y Luo… - Biomedicine & …, 2024 - Elsevier
Cancer poses a substantial global health challenge, necessitating the widespread use of
chemotherapy and radiotherapy. Despite these efforts, issues like resistance development …

Traditional Chinese medicine inhibits PD-1/PD-L1 axis to sensitize cancer immunotherapy: a literature review

H Zheng, G Wang, M Liu, H Cheng - Frontiers in Oncology, 2023 - frontiersin.org
The Programmed death-1 (PD-1) and its programmed death-ligand 1 (PD-L1) comprise the
PD-1/PD-L1 axis and maintain tumor immune evasion. Cancer immunotherapy based on …

Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway

Y Qin, W Li, J Liu, F Wang, W Zhou, L Xiao… - International …, 2024 - Elsevier
Autophagy in alveolar macrophages (AMs) is an important mechanism for maintaining
immune homeostasis and normal lung tissue function, and insufficient autophagy in AMs …